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Two catergine of synapses
Electrical and chemical. Majority of synapses in human brain are chemical
- Direct transfer of current from one cell to the next
- -current goes throught gap junctions
- -each channel=connexon
- -connexons made up of connexin proteins
addtion of connexon
post synaptic poential. Small compared to action potential is 1mv
Electrical synapses are
Bidirectional. Fast- no time delay . Ex escape reflexes in invertebrates
axon terminal with synaptic vesicles- store neurotransmitter
Post synaptic side
attach the synaptic vesicle to active zone.
synaptic vesicle docked at, and process
- presyneptic membrance by snare protiens. Acton potential arrives at axon terminal
- -voltage gated calcium channels open
- -calcium flows into presynaptic terminal
- vesicle fuses w/ presynaptic membrane
- -nerotransmitter released.
- vesicle recycled
- SNARE PROTEIN on synaptic vesicle
- - senses ca2+ increase and triggers release
what does tetanus toxin do?
Tetanus toxin released by bacteria has its effect by cutting snare protein.
synapse between neuron + muscle cell
Motor end plate=
- post-synaptic membrance-
- -is folded
- -larger surface area
- -many neuro-transmitter receptors
- aligned over folds
- -release of a large number of neurotransmitter molecules
- -large response in muscle cell to contraction
- -fail -safe
excitatory neurotransmitter example
At postsynaptic terinal after diffusing across synaptic clef what happens?
Neurontransmitter binds to neuro transmitter gated ion channels and then ion channel opens and if channel permeable to Na+ ions then EPSP(excitatory postsynaptic potential)
Inhibitory neurotransmitter example
Chemical synapses can be
inhibitory if neurotransmitter-gated ion channel is permable to CL- ions then IPSP (inhibtory post-synaptic potential)
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