Pharm II (Management of pain)
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What is the difference between Secondary to nerve injury and Nociceptive pain?
- Secondary to nerve injury
- -Responds poorly to opioids and NSAIDs
- Nociceptive pain
- -post-operative, due to trauma, arthritic
- -Responds to opioids and NSAIDs
What is Allodynia?
What is Hyperalgesia?
-Pain from stimulus that ordinarily does not elicit a painful response; e.g., light touch
-Increased sensitivity to a normally painful stimulus
What are some drug groups that are used in pain management?
- TCA and SNRI antidepressent drugs
- Local Anesthetics
- NE and 5-HT reuptake inhibition
- -Duloxetine- used for Diebetic Perioheral Neuropathy
What are the antiepileptic drugs that can be used for pain? what are they used for?
-carbamazepine-Approved for trigeminal neuralgia
- -pregabalin-PHN, Painful diabetic peripheral
- neuropathy, Fibromyalgia
What is lidocaine used for?
- -Approved for PHN
What are some other drugs that are approved for Neuropathic pain?
- Topical capsaicin
- -Depletes substance P
- -Has been studied in painful diabetic peripheral neuropathy
- α-2 agonists, eg, clonidine
- α-1 antagonists, eg, prazosin, terazosin
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