BC platelet plug #28.txt
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What is hemostasis?
What are the two parts of a thrombus?
What are the three events of a vascular injury?
- 1) vasoconstriction
- 2) Platelet plug
- 3) fibrin clot
What is the difference b/t thrombocytopenia and thrombocytosis?
- -cytopenia: not enough platelets
- -cytosis: too many plateles
What are the three granule types in platelets?
- Dense granules: ADP and Ca
- Alpha granules: vWF, fibrinogen, serotonin, PDGF
- Dense tubular system: Ca
What prostanoid is active in healthy individuals and what is its function?
PGI2: inhibits platelet formation
How does PGI2 function to stop platelet formation?
- binds Gs = cAMP
- cAMP activate dense tubular system
- dense tubular system uptakes Ca
- Less intracellular Ca = less platelet plug formation
What does shear force to to vWF-collagen binding?
Increases (happens in people with thrombi or hypertension)
What are the five steps of platelet plug formation?
- 1) Adhesion
- 2) Activation
- 3) degranulation/secretion
- 4) shape change
- 5) aggregation
What is the most potent agonist of platelet activation?
What G protein is used for activation?
What is the function of ADP and is it Autocrine or Paracrine?
- Increase platelet-aggregation
What is function of Plavix?
Inhibit ADP binding to its Autocrine receptor so platelet-aggregation is inhibited
What are the three important protein changes during the Shape Change?
- 1) GpIIa/IIIb
- 2) Phosphatidylserine flips out = more negative
- 3) negativity attracts VIIIa and Va = help with fibrin clot
What does GpIIIa/IIIb bind?
Fibrinogen that was secreted from Alpha granules
What is the binding site on fibrinogen?
What is the function of integrilin?
- Inhibit binding of fibrinogen to GpIIa/IIIb by competing with fibrinogen
- inhibit platelet aggregation
gWhich COX can recover after usage of low-dose aspirin and why?
COX-2 due to a nucleus
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