Exam 1

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Author:
KHW
ID:
65577
Filename:
Exam 1
Updated:
2011-02-10 20:37:23
Tags:
intro imm
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Exam 1
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  1. life span on neutrophils
    short
  2. 4 Major parameters/cells types of the innate immune:
    • inflammation
    • phagocytic cells
    • NK cells
    • Soluble defense factors
  3. Functions of TLR
    • Microbial recognition, engulfing & Killing
    • Mediate innate (inflammation)
    • Mediate Acquired (Humoral and CMI)
  4. Antigenicity-
    Abitility of Ag to bind to immune components
  5. Immunogenicity-
    The ability of an Ag to illicit an immune response
  6. Epitope-
    immunogenic part that binds to Ab or TLR
  7. APC's (3):
    • Dendritic Cells
    • Macrophages
    • B-Cells
  8. Professional APC=
    Dendritic Cells
  9. Semi-Pro APC=
    • Macrophages
    • B-Cells
  10. After Ag is captured, immature dendritic cells migrate to...
    Secondary Lymph tissues (ie LN)
  11. After AG is captured, MATURE dendritic cells migrate to...
    Secondary Lymph Tissue
  12. Endogenous Ag presents via...
    MHC I
  13. Exogenous Ag presents via...
    MHC II
  14. Exogenous APCs can also present endogenous Ag if via MHC I...
    Intracellularly infected
  15. MHC I: _____ Ag Processing to _____
    • Endogenous
    • Cytotoxic T
  16. MHC II: ____ Ag processing to _____
    • Exogenous
    • T-Helper
  17. CD-4=
    Cytotoxic
  18. CD-8+
    Helper
  19. MHC II is expressed only by...
    Phagocytic APCs
  20. MHC I is expressed by...
    All Nucleated Cells
  21. MHC I is active when...
    infected
  22. Specificity/Diversity of BCR's and TCRs is made possible by...
    Somatic Gene Rearrangement
  23. B & T cells mature within the ___ Lymph Tissue
    Primary
  24. Upon leaving the thymus, T-Cells are mature, but...
    Naieve until presented by MHC-Ag complex
  25. Effector B-Lymphocytes:
    Plasma Cells
  26. Effector T-Lymphocytes:
    • Th that aids other T & B cells
    • Tc that kill infected cells and tumor cells
  27. Tc Ag processing and differentiation occurs in the ____ Lymph Tiss
    Secondary
  28. The Tc receptor is located...
    membrane bound
  29. Ways in which a is T-cell activated:
    • Direct (TcR + MHC + Ag)
    • Costimulation (TcR + MHC + Ag + costim molecules)
  30. Tc is activated by..
    MHC II Ag presentation
  31. Th1 cytokines:
    • IL-2
    • IN-y
    • TNF
  32. IL-2->
    Activation of TCells, BCells & NK
  33. IN-y ->
    Activation of MO
  34. TNF ->
    Marks tumor cells
  35. Th2 Cytokines
    • IL-4
    • IL-5
    • IL-6
    • IL-10
  36. Functions of Th2 cytokines:
    • Stimulate B-call proliferation
    • Neutralizing Ab secretion
    • Resistance to extracellular pathogens
  37. Th2 killss:
    • Infected cells (w/ endogenous Ag)
    • Transformed cells (tumor Ag)
    • MHC Incompatible cells (non-self)
  38. B-Cells mature when...
    they react with Ag
  39. B-Cell receptor is located..
    in the membrane
  40. B-Cells are activated when
    • Ag binds to BCR
    • Th cell signal
  41. NK cells have receptors for:
    • Fc part of Ab
    • Complement Proteins
  42. NK Cells are regulated by:
    Cytokines
  43. NK Cells target cells that...
    • Dont express MHC I
    • Have abnormal Protein expression
    • Ab-Coated
    • Complement covered

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