HISTOLOGY-Lecture 2-Tissues & Extracellular Matrix

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lfield5
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65640
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HISTOLOGY-Lecture 2-Tissues & Extracellular Matrix
Updated:
2011-02-11 00:56:58
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HISTOLOGY
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Description:
Lecture 2-Tissues & Extracellular Matrix
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  1. Tissues (defininition & composition)
    group of cells that from similar strucural and functional associations

    • composed of -
    • Cells
    • Extracellular matrix
  2. Basic Tissues
    • epithelial
    • connective
    • nervous
    • muscle
  3. Extracellular Matrix (definition)
    • nonliving macromolecules
    • manufactured by cells
    • exported into extracellular space
    • composed of ground substane & fibers
  4. Ground Substance (composition)
    • Glycosaminoglycans - GAG
    • Proteoglycans
    • Adhesive Glycoproteins
    • Fibronectin
    • Laminin
    • Entactin
    • Tenascin
    • Chrondronectin
    • Ostronectin
  5. Glycosaminoglycans - GAG
    (composition)
    Carboxyl groups

    Sulfornated - all but one

    Amino groups

    Negative charge

    • Polysaccharides
    • -long rod-like chains
    • -inflexible
    • -unbranched
    • -repeating disaccharides
  6. Polysaccharides
    • long rod-like chains
    • inflexible
    • unbranched
    • repeating disaccharides
  7. Negative charge of Ground Substance
    attracts Na+

    Na+ attracts water

    water resists compression

    will form covalent bonds with proteins
  8. Ground Substance
    (protein bonding examples)
    keratin sulfate

    heparin sulfate

    heparin

    chondroitin-4-sulfate

    chondroitin-6-sulfate

    cermatan sulfate

    hayaluronic acid - nonsulfated

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