agents that inhibit protein synthesis: cobalt, aminotriazole.
agents that affect tissue levels of necessary cofactors: sulfoximine inhibits GSH synthesis, diethyl maleate depletes GSH.
- agents that inhibit P450:
- - CO: competes with oxygen for heme in cytochrome.
- - SKF 525-A, piperonyl butoxide: are noncompetitive inhibitors.
- -suicide inhibition, activated metabolites bind to heme. examples, carbon tetrachloride and vinyl chloride.
simple or complex inhibition: some agents inhibit both phase I and II reactions