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What is a prosthetic group?
Which enzymes show sigmoidal action curves?
Most enzymes show what kind of action curve?
A high Km suggest what?
- Small affinity for substrate
What effect does a competitive inhibitor have on Km?
- Makes it higher
- i.e---lowers the affinity of the enzyme for the substrate
What effect does a competitive inhibitor have on Vmax and Km?
Vmax is the same and Km is increased
Enzyme capable of being competitively inhibited?
- HMG-Coa reductase
- inhibitor--crestor, lipitor, lovastatin
What effect does a noncompetitive inhibitor have on Vmax and Km?
- decreases Vmax
- unchanged Km
What effect does an uncompetitive inhibitor have on an enzyme?
What is a homotropic effector?
substrate is the effector
What is a heterotropic effector?
substance other than substrate has an effect on an enzyme
What are two enzymes indivative of myocardial infarction?
Type III collagen, Ehlers-Danlos Syndrom.. deficient enzyme?
What would be deficient?
Deamination of Cytosine to Uracil would be corrected by?
Base excision repair
defective in what condtion?
- Wrong bases are inserted
Ciproflaxin inhibits what?
Nitrous acid does what to bases?
Sigma subunit of RNA polymerase does what?
Sigma--Starts transcription by recognizing and binding to the promoter
In what a.a are cis bonds possible?
Drug similar to aminoacyl-tRNA?
What are the sizes the the follwing vectors can carry?
What does a Genomic Library contain?
Exons and Introns
What does a cDNA library contain?
Jaundice presents in the eye
Isochromosome results from what genetic phenomenon?
2 acrocentric chromosomes join end to end
An Isochromosome 21 carrier has what chance of having a child with a trisomy 21?
What does not alter the allelic frequency in a population?
Both chromosomes inherited from one parent
Male to male transmission?
2 conditions that are x linked dominant?
- RETT--lethal in males..otherwise..klinefelters
- Vit D resistant rickets--hypophosphatemia
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