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What is a prosthetic group?
Which enzymes show sigmoidal action curves?
Most enzymes show what kind of action curve?
A high Km suggest what?
Small affinity for substrate
What effect does a competitive inhibitor have on Km?
Makes it higher
i.e---lowers the affinity of the enzyme for the substrate
What effect does a competitive inhibitor have on Vmax and Km?
Vmax is the same and Km is increased
Enzyme capable of being competitively inhibited?
inhibitor--crestor, lipitor, lovastatin
What effect does a noncompetitive inhibitor have on Vmax and Km?
What effect does an uncompetitive inhibitor have on an enzyme?
What is a homotropic effector?
substrate is the effector
What is a heterotropic effector?
substance other than substrate has an effect on an enzyme
What are two enzymes indivative of myocardial infarction?
Type III collagen, Ehlers-Danlos Syndrom.. deficient enzyme?
What would be deficient?
Deamination of Cytosine to Uracil would be corrected by?
Base excision repair
defective in what condtion?
Wrong bases are inserted
Ciproflaxin inhibits what?
Nitrous acid does what to bases?
Sigma subunit of RNA polymerase does what?
Sigma--Starts transcription by recognizing and binding to the promoter
In what a.a are cis bonds possible?
Drug similar to aminoacyl-tRNA?
What are the sizes the the follwing vectors can carry?
What does a Genomic Library contain?
Exons and Introns
What does a cDNA library contain?
Jaundice presents in the eye
Isochromosome results from what genetic phenomenon?
2 acrocentric chromosomes join end to end
An Isochromosome 21 carrier has what chance of having a child with a trisomy 21?
What does not alter the allelic frequency in a population?
Both chromosomes inherited from one parent
Male to male transmission?
2 conditions that are x linked dominant?
RETT--lethal in males..otherwise..klinefelters
Vit D resistant rickets--hypophosphatemia