They may alter the __of the genetic message, the triplet grouping of bases on the mRNA that is read during translation.
· Such a mutation, called a __, will occur whenever the number of nucleotides inserted or deleted is not a multiple of three. All the nucleotides that are downstream of the deletion or insertion will be improperly grouped into codons, and the result will be extensive missense, usually ending sooner or later in nonsense and premature termination. Unless the __is very near the end of the gene, the protein is almost certain to be nonfunctional.
- reading frame
- frameshift mutation