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What are the three complexes of fibrin formation?
What cells can store factors V and VIII?
Alpha-granules within platelets
Where is the Tissue Factor found for the initiation complex?
Where are the tenase and prothrombinase complexes found?
What is the name for factors I, II, III, IV, XIII?
- I: Fibrinogen
- II: Prothrombin
- III: Tissue Factor
- IV: Ca2+
- XIII: transglutaminase
What two factors do not need to be cleaved in order to be activated?
III (TF) and IV
What four factors are K sensitive and what is their order of sensitivity? What proteins are K sensitive?
- Proteins: C & S
What drug can be used to inhibit Vitamin K usage for GLA residues?
What fibrinopeptides must be removed from fibrinogen to activate the binding between D and E sites?
Fibrinopeptide A and B
What two molecules line up to bind fibrinogens together?
Glycine and Leucine
What factor builds cross-linking between fibrinogen?
What factor destroys fibrin clots?
What three factors activate plasmin?
What factor inhibits the plasmin activators?
What factor inhibits free plasmin?
What clotting factors are inhibited by ATIII?
IX, X, II
What is the order of sensitivity to ATIII?
IX, X, II
What two factors are inhibited by TFPi?
How is protein C activated for platelet degradation?
- Thrombin binds thrombomodulin
- Thrombin comes in to close vicinity of Protein C
- Thrombin cleaves protein C
- APC is activated with Protein S cofactor
- APC binds to Factors V and VIII
What is the Leiden mutation?
- When factor V is not susceptible to APC degradation
- ***problem b/c they are prone to hyperthrombosis
What is Hemophilia A and B?
- A: Deficient VIII factor (tenase complex)
- B: deficient IX factor (tenase complex)
Which hemophilia is more common, A or B?
What is the difference b/t a white clot and a red clot?
- White clot: just platelet plug/aggregation
- Red Clot: fibrin w/ trapped RBC, generally venous thrombi
What is Disseminated intravascular coagulation? (DIC)
- inflammation induced coagulation
- Two problems:
- 1) formation of fibrin clots
- 2) high platele aggregation steals clotting factors so excessive bleeding can occur in other parts of the body