1) Clavulanic Acid
They are suicide substrates
for the b-lactamase enzyme.
They are potent inhibitors
against Beta Lactamases and cause prolonged inactivation of Group A b-lactamases
; other b-lactamase
groups are resistant.
They exhibit a very weak antibacterial activity
(ie, they are weak inhibitors of PBPs).
They are used in combination with b-lactamase-sensitive penicillins
to treat b-lactamase-producing infections. These Beta Lactamase Inhibitors can't kill bacterial cells, which is why we use them in combination with another antibiotic.
Class I are highly electronegative
because of the Oxygen, Sulfur and Nitrogen species in the bonds (see below).
- Cross-linking takes place, but there is prolonged inactivation of the Beta Lactamase enzyme, which allows the antibiotic used in combination to go in and do its thing.