N304 Antiemetics

Card Set Information

Author:
cbishop
ID:
66751
Filename:
N304 Antiemetics
Updated:
2011-02-16 12:39:24
Tags:
N304 Antiemetics
Folders:

Description:
304 antiemetics 2.14
Show Answers:

Home > Flashcards > Print Preview

The flashcards below were created by user cbishop on FreezingBlue Flashcards. What would you like to do?


  1. Where is the vomiting center in the brain?
    The reticular formation of the medulla
  2. What kind of effecct do anti-histamines have?
    An anticholinergic effect
  3. What are the uses for Anti-histamines?
    • Simple nausea
    • Motion sickness
    • Vertigo
    • Meniere's syndrome(inner ear problems)
    • *This works on the inner ear, so that is why it helps with motion sickness, vertigo, meniere's, etc.
  4. Dimenhydrinate (Dramamine)
    Antihistamine/Anticholergics
  5. Diphenhydramine (Benadryl)
    Antihistamine/Anticholergics
  6. Hydroxyzine (Atarax, Vistaril)
    Antihistamine/Anticholergics
  7. Trimethobenzamide (Tigan)
    Antihistamine/Anticholergics
  8. What are the SE of the anti-histamines?
    • CNS- sedation, dizziness, HA, lassitude
    • Anticholinergic effects:
    • (constipation, blurred vision, dry mouth, sleepiness)
  9. What is lassitude?
    Feeling like "I don't want to"
  10. What do phenothiazine antiemetics do?
    Block dopamine receptors in CTZ
  11. What is CTZ?
    Chemoreceptor Trigger Zone
  12. Waht are phenothiazine used for?
    • Severe N/V.
    • Can be used for motion sickness as well.

    Originally used for psychoses -- but in larger doses
  13. Prochlorperazine (Copazine)
    Phenothiazine antiemetic
  14. Promethazine (Phenergan)
    • Phenothiazine antiemetic
    • *sometimes used pre-post- op for nausea
  15. What are the interactions for phenothiazine anti-emetics?
    • CNS depressants (additative)
    • Anticholinergics***
  16. What are the side effects for phenothiazine antiemetics?
    Sedation, hypotension, EPS (extrapyramidal symptoms--EPS include parkinsonism, akathisia, dystonia, and tardive dyskinesia)

    Confusion in the elderly

    Lower seizure threshold -- so they will have more seizures if they already have them
  17. Benzquinamide (Emete-con)
    Usually used periop.-prob. Acts in chemo receptor trigger zone
  18. Metoclorpramide (Reglan)
    Increases GI motility- if you give too much, pt will have the runs

    Does antagonize dopamine receptors in the CTZ and CNS
  19. Dronabinol (Marinol)
    • Legal pot
    • THC- active ingredient in pot
    • Can lead to dependence

    SE: mood changes, memory loss, sleep disorders, altered time perception, poor impulse control
  20. Scopolamine transdermal
    motion sickness patch
  21. What are 5HT3 blockers?
    AKA serotonin type 3 recpetor antagonists

    • *block receptors in brain and GI tract
    • *really helpdul for pt on chemo, to help with NV
    • *"-tron" medications
  22. ondansetron (Zofran)
    • 5HT3 blockers (serotonin antagonists)
    • *give 30 min before a first chemo dose
    • *IV or dissolving tab
    • *SE: diarrhea, constipation, HA, rash, inc liver enzymes
  23. Granisetron [kytril]
    5HT3 Blockers- serotitonin antagonists

    • *excreted in urine and feces
    • *Start 30 min before a chemo dose. Only given on chemo dats, once a day
    • *SE: HA, asthenia-loss of strength, somnolence-sleepy, diarrhea, (or) constipation, FEVER (let patient know this is a SE)
  24. Dolasetron [Anzemet]
    • 5HT3 Blockers, serotonin antagonists
    • *PO or IV (both work the same)
    • *single dose a chemo
    • *SE: HA, diarrhea, FEVER, fatigue, ABD pain, transient PR & QT changes in EKG-- nut nothing too significant.
  25. Aprepitant [Emend]
    *Substance P/Nk1 Receptor

    • *give 1 hour a chemo (1st day), 2nd day (lower dosage PO)
    • *SE: dizziness, weakness, hiccups, ,diarrhea
    • *many interactions (at least coumadin and dilantin)
  26. Megestrol Acetate (Megace)
    • Artificial progesterone-- not quite sure how it works
    • Increases appetite (helps with cachexia)
    • SE: edema, diarrhea
    • Gets weight back on person, but not muscle mass, so it doesn't cure cachexia.

What would you like to do?

Home > Flashcards > Print Preview