Breast Cancer

Card Set Information

Author:
giddyupp
ID:
66864
Filename:
Breast Cancer
Updated:
2011-02-17 11:46:52
Tags:
Breast Cancer PHPR523 Test3
Folders:

Description:
Breast Cancer
Show Answers:

Home > Flashcards > Print Preview

The flashcards below were created by user giddyupp on FreezingBlue Flashcards. What would you like to do?


  1. What are the NCCN recommendations for the use of Tamoxifen and Raloxifene to reduce the risk of breast cancer?
    • Tamoxifen:
    • Pre and Postmenopausal
    • 20mg/d x 5y
    • Raloxifene:
    • Postmenopausal only
    • 60mg/d x 5y
  2. What are the Antiestrogen meds?
    • Tamoxifen
    • Raloxifene
    • Toremifene
    • Fulvestrant
  3. What are the common SE of Antiestrogens?
    • Thromboembolic events (Stroke, PE, DVT)
    • Hot flashes
    • Endometrial cancer risk
    • Ischemic heart disease
    • Bone fractures
  4. What is the method of action of Antiestrogens?
    Competes with estrogen for binding sites in breast and other tissues
  5. What are the Aromatase inhibitor meds?
    • Anastrazole
    • Exemestane
    • Letrozole
  6. What are the common SE of Aromatase inhibitors?
    • Thromboembolic events (Stroke, PE, DVT - possibly less than antiestrogens)
    • Hot flashes
    • Endometrial cancer risk
  7. What is the MOA of Aromatase inhibitors?
    Block aromatase enzyme from converting androgen to estrogen (only useful Postmenopause because only adipose tissue is making estrogen)
  8. What antineoplastic agents are used to treat breast cancer?
    • Capecitabine
    • Cyclophosphamide
    • Docetaxel
    • Doxorubicin
    • Epirubicin
    • Fluorouracil
    • Lapatanib
    • Ixabepilone
    • Methotrexate
    • Trastuzumab
    • Paclitaxel
  9. What is the treatment for Lobular Carcinoma in situ (LCIS) in breast cancer?
    Observation + Tamoxifen or Raloxifene
  10. What is the tx for Ductal Carcinoma in situ (DCIS) in breast cancer?
    Surgery +/- RT +Tamoxifen (if ER positive)
  11. What is the tx for Stage I or II invasive carcinoma in breast cancer?
    • Surgery +/- RT +/- Adjuvant tx (if tumor > 1cm)
    • Trastuzumab required if HER2/neu positive
  12. What is the tx for Stage III invasive carcinoma in breast cancer?
    • Operable: Surgery + Adjuvant tx
    • Inoperable: Neoadjuvant chemotherapy then Surgery then RT + Chemotherapy +/- Endocrine tx (only if ER/PR positive)
  13. What is the tx for Stage IV (Metastatic) invasive carcinoma in breast cancer?
    • Endocrine tx OR chemotherapy + bisphosphonates (for bony mets only)
    • If ER/PR positive, bone or soft tissue disease, or limited asymptomatic visceral disease, you use Endocrine tx
    • If ECOG = 3 or more, or if failed 3 sequential chemo regimens, give supportive care only
  14. What is the adjuvant tx used for Stage I, II, or III breast cancer?
    • TAC: Docetaxel, Doxorubicin, and Cyclophosphamide (+CSF)
    • Dose-Dense AC (q 14d) + Paclitaxel: Doxorubicin + Cyclophosphamide, then Paclitaxel (+CSF)
    • AC (q 21d) + Paclitaxel: Doxorubicin + Cyclophosphamide, then Paclitaxel
    • TC: Docetaxel + Cyclophosphamide
    • AC: Doxorubicin + Cyclophosphamide
    • AC + TH (HER2/neu positive): Doxorubicin + Cyclophosphamide, then Docetaxel + Trastuzumab
    • TCH (HER2/neu positive): Docetaxel + Carboplatin + Trastuzumab
  15. What is the endocrine tx for premenopausal metastatic or recurrent breast cancer?
    • Ovarian ablation/suppression, Surgery (oophorectomy), or RT +:
    • Aromatase inhibitor
    • Antiestrogen
    • Megestrol acetate
    • Fluoxymesterone
    • Ethinyl estradiol
  16. What is the chemotherapy for metastatic or recurrent breast cancer?
    • Single agent:
    • Doxorubicin
    • Epirubicin
    • Liposomal doxorubicin
    • Paclitaxel
    • Albumin-bound paclitaxel
    • Docetaxel
    • Capecitabine
    • Vinorelbine
    • Eribulin
    • Combination regimens:
    • FAC/CAF (cyclophosphamide, doxorubicin, and 5-FU)
    • CEF (5-FU, epirubicin, and cyclophosphamide)
    • AC (doxorubicin + cyclophosphamide)
    • EC (epirubicin + cyclophosphamide)
    • AT (doxorubicin + docetaxel OR paclitaxel)
    • CMF (cyclophosphamide, methotrexate, and F-FU)
    • Docetaxel/capecitabine
    • Gemcitabine/paclitaxel
    • Ixabepilone + capecitabine
    • HER2/new positive:
    • Trastuzumab + Paclitaxel +/- Carboplatin
    • Trastuzumab + Docetaxel
    • Trastuzumab + Vinorelbine
    • Trastuzumab + capecitabine
    • Lapatinib + Capecitabine
    • Lapatinib + Trastuzumab

What would you like to do?

Home > Flashcards > Print Preview