Lung Cancer

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Author:
giddyupp
ID:
67067
Filename:
Lung Cancer
Updated:
2011-02-17 14:03:34
Tags:
Lung Cancer PHPR523 Test3
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Description:
Lung Cancer
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  1. What is the significance of EGFR mutations in NSCLC?
    these mutations increase effectiveness of Tyrosine Kinase Inhibitors (erlotinib, gefitinib)
  2. What is the significance of K-ras mutations in NSCLC?
    these mutations decrease the effectiveness of Tirosine Kinase Inhibitors (erlotinib, gefitinb)
  3. What drugs are used to treat NSCLC?
    • Bevacizumab
    • Carboplatin
    • Cetuximab
    • Cisplatin
    • Docetaxel
    • Erlotinib
    • Etoposide
    • Gemcitabine
    • Paclitaxel
    • Pemetrexed
    • Vinblastine
    • Vinorelbine
  4. What drugs are used to treat SCLC?
    • Carboplatin
    • Cisplatin
    • Etoposide
  5. What are the types of NSCLC?
    • Non-squamous: adenocarcinoma and large cell carcinoma
    • Squamous
  6. What are the types of SCLC?
    • Oat cell
    • Intermediate cell
  7. What are the Paraneoplastic syndromes associated with lung cancer (esp. SCLC)?
    • Cushing's syndrome
    • Hypercalcemia
    • SIADH
    • Pulmonary hypertrophic osteoarthropathy
    • Eaton-Lamber myasthenic syndrome
  8. What are the treatment strategies for NSCLC?
    • Stage I: Surgical resection +/- Adjuvant tx +/- RT
    • Stage II: Surgical resection + Adjuvant tx +/- RT
    • Stage III: Surgical resection + Adjuvant tx +/- RT (Unresectable = RT + Adjuvant tx)
    • Stage IV: Chemotherapy (if good performance status)
  9. What is the adjuvant tx for Stage I-III in NSCLC?
    • Cisplatin + Vinorelbine
    • Cisplatin + Etoposide
    • Cisplatin + Vinblastine
    • Paclitaxel + Carboplatin (only for pts w/ comorbidities or unable to tolerate Cisplatin)
    • Cisplatin + Gemcitabine
    • Cisplatin + Docetaxel
    • Cisplatin + Pemetrexed (Non-squamous only)
  10. What is the chemotherapy used for Stage IV NSCLC?
    • Carboplatin + Paclitaxel + Bevacizumab (Non-squamous only, No CNS mets, No hemoptysis, No anticoag)
    • Cisplatin + Vinorelbine + Cetuximab
    • Erlotinib (Non-squamous, EGFR positive, K-RAS negative only)
    • For those not candidates for Bevacizumab or Cetuximab:
    • Cisplatin +:
    • Pemetrexed (non-squamous only)
    • Paclitaxel
    • Gemcitabine
    • Docetaxel
    • Vinorelbine
    • Carboplatin +:
    • Gemcitabine
    • Docetaxel
    • Pemetrexed (Non-squamous only)
    • Non-platinum based:
    • Gemcitabine + Docetaxel
  11. What is the maintenance tx for NSCLC?
    • Pemetrexed
    • Erlotinib
    • Docetaxel
    • Non-squamous only
    • Only if no progression during or after 4-6 cycles
  12. What is the second-line tx for NSCLC if maintenance tx fails?
    • Docetaxel
    • Pemetrexed
    • Erlotinib
  13. What is the third-line tx for NSCLC if second-line tx fails?
    • Erlotinib (stat superior to best supportive care with respect to survival)
    • Best supportive care
    • Clinical trial
  14. What are the stages of SCLC?
    • Limited: good PS, female, age<70, normal LDH
    • Extensive: normal LDH, single metastatic site
  15. What is the tx for Limited SCLC?
    • Surgery + chemo +/- RT
    • Etoposide + Cisplatin or Carboplatin
  16. What is the tx for Extensive SCLC?
    • Etoposide + Cisplatin or Carboplatin
    • Irinotecan + Cisplatin or Carboplatin
  17. What is salvage tx for SCLC if relapse <2-3 months?
    • Ifosfamide
    • Paclitaxel
    • Docetaxel
    • Gemcitabine
    • Topotecan
    • Irinotecan
  18. What is the salvage tx for SCLC if relapse >2-3 months and <6 months?
    • Topotecan
    • Irinotecan
    • CAV (Cyclophosphamide + Doxorubicin + Vincristine)
    • Gemcitabine
    • Paclitaxel
    • Docetaxel
    • Etoposide (PO)
    • Vinorelbine
  19. What is the salvage tx for SCLC if relapse > 6 months?
    original regimen

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