Colon Cancer

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Author:
giddyupp
ID:
67081
Filename:
Colon Cancer
Updated:
2011-02-17 15:26:39
Tags:
Colon Cancer PHPR523 Test3
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Description:
Colon Cancer
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  1. What agents are used in Colon Cancer?
    • Bevacizumab
    • Capecitabine
    • Cetuximab
    • Fluorouracil
    • Irinotecan
    • Oxaliplatin
    • Panitumumab
  2. What are the risk factors associated with colon cancer?
    • Increase risk:
    • Alcohol > 10-14/wk
    • DM
    • Obesity + inactivity
    • Tobacco use
    • Western Diet
    • Ulcerative colitis
    • Crohn's disease
    • Familial Adenomatous Polyposis (FAP)
    • Hereditary nonpolyposis colon cancer(HNPCC)
    • Decrease risk:
    • ASA
    • NSAIDs
    • Ca + Vit D
    • Postmenopausal HRT
  3. What prognostic factors are used to determine tx in colon cancer?
    • Depth of tumor in bowel wall
    • Presence in lymph nodes
    • Bowel obstruction or perforation, rectal bleeding
    • High pre-op CEA (carcinoembryonic antigen)
    • Distant metastasis
    • K-RAS mutations no MABs
    • BRAF mutations no MABs
    • DNA mismatch repair (MMR) no 5-FU
  4. What are the stages of Colon Cancer?
    • Stage I: depth has not breached the submucosa
    • Stage II: breached the submucosa, lymph nodes negative
    • Stage III: Lymph nodes positive, no mets
    • Stage IV: Metastatic
  5. What is the tx strategy for colon cancer?
    • Stage I: Surgery
    • Stage II: Surgery + Adjuvant tx
    • Stage III: Surgery + Adjuvant tx
    • Stage IV (isolated): Neoadjuvant tx, then Surgery, then Adjuvant tx
    • Stage IV (disseminated): Chemotherapy (if PS < 3)
  6. What is the adjuvant tx for Stages II and III in colon cancer?
    • 5-FU + Leucovorin
    • Capecitabine
    • FLOX (5-FU bolus + Leucovorin + Oxaliplatin)
    • FOLFOX (5-FU infusion + Leucovorin + Oxaliplatin)
  7. What is the first-line chemotherapy for advanced (disseminated) or recurrent colon cancer?
    • FOLFOX +/- Bevacizumab (5-FU + Leucovorin + Oxaliplatin)
    • CapeOX +/- Bevacizumab (Capecitabine + Oxaliplatin)
    • FOLFOX +/- Cetuximab or Panitumumab
    • FOLFIRI + Bevacizumab (5-FU + Leucovorin + Irinotecan)
    • FOLFIRI +/- Cetuximab or Panitumumab
    • Capecitabine +/- Bevacizumab
    • FOLFOXIRI (5-FU + Leucovorin + Oxaliplatin + Irinotecan)
  8. What is the second-line tx for advanced (disseminated) or recurrent colon cancer?
    • FOLFIRI
    • Irinotecan
    • FOLFIRI + Cetuximab or Panitumumab (5-FU + Leucovorin + Irinotecan)
    • Cetuximab + Irinotecan
    • FOLFOX (5-FU + Leucovorin + Oxaliplatin)
    • CapeOX (Capecitain + Oxaliplatin)
    • Cetuximab
    • Panitumumab
  9. What is the salvage tx for advanced (disseminated) or recurrent colon cancer?
    • Cetuximab
    • Panitumumab
    • Cetuximab + Irinotecan
    • FOLFOX (5-FU + Leucovorin + Oxaliplatin)
    • CapeOX (Capecitabine + Oxaliplatin)
    • Irinotecan, then Cetuximab (or Panitumumab or Cetuximab + Irinotecan)
    • Clinical trial or best supportive care

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