Card Set Information
drugs are one of the tools used in the treatment of malignant diseases
therapy used with antineoplastics?
spreading of the cancer to other sites?
comfort care, the relief of symptoms at the end of life?
list the 5 phases of cell growth?
G1-RNA and proteins are built
s- DNA is made from the components of G1.
G2- mitotic cell division (doubled and split in 2 divisions)
G0- the dormant resting phase
this targets the cell in one of the phases of cell division
they can target the cell at any phase of the cycle?
localized tumor that has fibrous capsule, limited growth, reg shape, well differentiated. does not invade other tissue or have mets
grows, invades and has mets. irregular shape and composed of poor differentiated cells, can result in death
this type of cell has no enclosing capsule?
this is a tumor that develops away from the sit or orgin?
when is chemo given to optimize cell death?
when the cells are splitting
what percentage of cells are killed during the first round of chemo?
during the second round of chemo what percentage is killed?
another 90% of the remaining
this therapy is designed to relieve or reduce intensity of uncomfortable symptoms
to reduce the bulk of the tumor, control bleeding and remove blockage
reduce tumor size, limits mets, allieve pain, bleeding and obstruction
reduce tumor size and limit mets
chemo can lead to what physical developments?
how is chemo administered?
systemically and affects normal and irregular cells
CCS are common to treat what type of cancers?
luekemia, lymphomas and solid tumors
drugs derived from vinca, alkaloids, taxanes, podophyllotoxins and camptothenin analog drugs?
plant alkaloids- CCS drugs
drug or other substance that is an antagonist or that resembles a normal human metabolite and interes with its function in the body
antimetabolite drugs - CCS
usually competes with the metabolites receptors or enzymes, interferes with the synthesis of RNA and DNA which makes it impossible for the cells to divide
CCS antimetabolite drugs
example of antimetabolite drugs?
methotrexate/ folic acid
this drug is does dependent?
used to cure,control, and provide palliation in the treatment of leukemias, lymphoma and diff solid tumors and certain autoimmune disease
examples of alkalating agents?
vincristine and vinbrlastine from periwinkle plant
agents that bond with DNA molecules and prevent cell division. will bond with DNA during any mitosis stage
interferes with DNA and RNA synthesis, delaying or inhibiting cell dividing and blocking the reproductive ability
examples of antineoplastic antibiotics?
adriamycin, used in treatment of solid tumors
substance that acts to alter the immune response by augumenting the bodys defense mechanisms or changing the way the body respons to cancer?
adverse reactions of antineoplastics?
the immediate would be n/v
a prevention to help n/v ?
giving a antiemetic before an antineoplastic
other adverse reactions of antineoplastics?
bone marrow suppression, anemia, leukopenia, thrombocytopenia, stomatitis, diarrhea, hair loss
some adverse reactions of alkaloids?
peripheral tingling sensation to hand and feet, tiny capillary leaks, skin color changes
help reduce the toxicity of chemotherapeutic agents to normal cells
estrogen, a hormonal agent is used to treat what tumor that is hormone dependent?
post menopausal breast cancer
what do androgen hormonal agents treat?
metastatic breast cancer of any age
estrogen can also treat what kind of tumor in men?
this hormonal agent is used to treat lymphomas and leukemias
antineoplastic drugs are contraindicated in pt with?
leukopenia, thrombocytopenia, anemia, serious infections, serious renal disease, HTN, during pregnancy or lactation
these drugs are used with antineoplastics to protect normal cells or organs of the body?