kumar gi packet 1

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kumar gi packet 1
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2011-02-20 21:35:39
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  1. appetite stimulants
    -gaba

    -opiates
  2. appetite suppressants
    -serotonin

    -calcitonin
  3. Benzodiapepines (appetite stimulants)

    What are the drugs and in who
    -Diazepam, oxazepam

    -most effective in cats
  4. Cyproheptadine ....what is it?
    • appetite stimulant
    • -anti-serotonin action
  5. Fenfluramine
    • -anoretic agents by increasing serotonin level
    • -withdrawn from the market bc heart valve disease
  6. Slentrol
    anti-obesity in dogs
  7. Ipecac
    • -emetic
    • -30 minutes until onset of action
    • -can use 2 doses
    • -NEVER USE IN CATS
  8. Apomorphine hydrochloride
    • -derivative of morphine
    • -ONLY IN DOGS
    • -SINGLE DOSE
    • -2-10 min onset
    • - not for animals with central depression
    • -use in the eyeball....can remove it when the dog pukes
  9. xylazine
    • -induces vomiting in cats
    • -side effect=bradycardia
  10. anti-histiminergics (centrally acting)
    • -blocks pukes caused by motion sickness or inner ear disease
    • -block h1 receptors at vestibular apparatus, and at CTZ and emetic center
    • -side effects xerostomia, drowsiness
  11. anti-muscarinics (centrally acting emetic)
    • -can penetrate the blood brain barrier
    • -used to control motion sickness in dogs
    • -side effects = xerostomia, drowsiness, constipation
  12. centrally acting anti-emetics
    block impulses at higher center and emetic center

    • -antihistiminergics
    • -antimuscarinics
    • -antidopaminergics
  13. anti-emetic drugs a CTZ
    • (peanut butter makes pies)
    • -phenothiazine
    • -butyrophenones
    • -metoclopramide
    • -peripherial 5-HT3, serotonin antagonists
  14. Phenoithiazine
    • -ctz
    • -anti-dop, anti-hist, anti-cholinergic properties
    • -broad spectrum antiemetic (blocks vomiting an czt and emetic center)
  15. what are the phenothiazine drugs?
    • -chlorpromazine
    • -acepromazine
    • -prochlorperazine

    • -not for animals with seizures bc it lowers threshold for seizures
    • -causes sedation and hypotension
  16. butyrophenones

    what are the drugs, and what does it do?
    • -haloperidol, droperidol
    • -major tranquilizer with anti-emetic action
    • -antagonizes dopamine receptors
    • -side effects = hypotension and sedation
    • -ctz
  17. metoclopramide
    • -dopamine and serotonin receptor antag.
    • -anti-emetic at ctz
    • -IT ANTAGONIZES APOMORPHINE INDUCED EMESIS
    • -side effects are hyperactivity, restlessness, tremors, constipation
  18. peripherial 5-HT3, serotonin antagonists
    • -anti-emetic at ctz and chemotherapeutic agents
    • -blocks serotonin receptors in git
    • -
  19. Cyproheptadine
    • -peripherial 5-HT3
    • -ondansteron-control emesis induced by chemotherapeutic agents/radiation therapy
  20. cerenia
    • -new anti-emetic drug for dogs
    • -preventing motion sickness
    • -
  21. peripherally acting anti-emetics
    ...what do they do?
    • drugs that protect GI from gastric irritation
    • -antacids
  22. anticholinergics
    • -decrease gi motility
    • -inhibit peripheral cholinergic transmission
    • -do not cross the blood brian marrier
    • -inhibit vagal afferent impulses
    • -relief of gi smooth muscle spasms
    • -inhibit gastro-emetic secretions
  23. histamine
    -gi secretions ....duh
  24. pgs
    -increase the mucous and bicarb secretion
  25. anti-cholinergics
    decrease gastric secretory
  26. atropine and propantheline
    • -decreases gastric motility and secretion
    • -(anti-cholinergics)
  27. pirenzepine
    • -reduces food-induced gastric acid secretion
    • -anti cholinergic
  28. H2 receptor antagonists
    -famotidine>ramtinidine=nizatidine>cimetidine
  29. Cimetidine
    • -well absorbed; food delays absorption
    • -give frequently
    • -(gastric anti-sec. drug)
  30. Ranitidine
    • -not impaired by food
    • -gastric anti-sec. drug
  31. famotidine
    • -poor oral absorption
    • -most potent
    • -gasric-anti sec drug
  32. nizatidine
    • -rapidally and completely absorbed
    • -preferred drug for patients with hepatic disease (eliminated by renal excretion)
  33. H2 antagonists....what for?
    ulcers
  34. omeprazole
    • -proton pump inhibitor
    • -irreversible inhib of proton pump
    • -bypasses the stomach and is absorbed in small intestines (parietal cells) to block it.
    • -use for ulcers
    • used in combination therapy

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