Ch18 Genetics Viruses

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clugster
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67873
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Ch18 Genetics Viruses
Updated:
2011-03-21 11:46:15
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Ch18
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Ch18
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  1. What is viral genetics?
    viruses and viroids are nonliving particles with nucleic acid genomes that require the assistance of living cells to reproduce
  2. What is viruses?
    • A) small infectious particle that consists of nucleic acid enclosed in a protein coat
    • B) over 4000 different types
    • C) vary greatly in their characteristics, host range, structure and genome composition
  3. What is the difference about their structural?
    • All have a capsid (protein coat) but it varies in shape and complexity
    • Some have viral envelope derived from host cell plasma membrane
  4. What kind of Genome of Viruses have?
    • DNA vs RNA
    • Single stranded vs Double stranded
    • Linear vs Circular
  5. What about their reproduction?
    Viruses are not alive therefore they are not cells or composed of cells. They also cannot carry out metabolism on their own.
  6. The basic steps of viruses are:
    • Attachment
    • Entry
    • Intregration
    • Synthesis of viral components
    • Viral assembly
    • Release
  7. What is the attachment?
    Usually specific for one kind of cell due to binding to specific molecules on cell surface
  8. What about the entry?
    • Bacteriophages or phage to injects only DNA into bacteria
    • HIV fuses with host membrane and the entire virus enters
    • Some viral genes are expressed
    • Virus may integrate into host chromosome
  9. What about integration?
    • It cuts host chromosomal DNA and insert viral genome.
    • Phage in bacterial DNA called prophage
    • HIV is an RNA Virus and integrates as a provirus
  10. What is the synthesis of viral components?
    • Host cell enzymes such as DNA polymerase make alot copies of the phage DNA; transcribe the genes within these copies into mRNA.
    • DNA provirus is not excised from hose chromosome instead it is transcribed in the nucleus to produce many copies of viral RNA.
  11. Viral assembly
    • Some viruses can self-assemble
    • Proteins modify capsid proteins or serve as scaffolding
  12. Release
    • Phages must lyse their host cell to escape.
    • Enveloped viruses bud from the host cell.
  13. What is lysogency?
    latency in bacteriophages. When host replicates, also copies prophage.
  14. What is the lysogenic cycle?
    Integration, replication and excision
  15. What is the lytic cycle?
    Synthesis, assembly and release
  16. Temperate Phages
    have a lysogenic cycle.
  17. Virulent phages
    do not have lysogenic cycle.
  18. Viriods
    • Composed solely of single-stranded circular RNA molecules
    • Infect plant cells
    • Some replicate in host cell nucleus, others in chloroplast
    • RNA genome does not code for proteins
  19. Prions
    • Composed entirely of proteins
    • Proteinaceous infectious agent
    • Dz causing conformation PrPSc
    • Converts normal proteins to abnormal conformation
    • Several types of neurodegenerative dz of human and livestock such as TSE (transmissible spongiform encephalopathies)

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