What allows for long-term regulation of blood flow?
Angiogenesis is the increase or decrease in the number of blood vessels can occur.
Angiogenesis can occur in response to ischemia (such as in frequent high intensity exercise).
When ischemia is present over the long term, tissues release angiogenic factors (VEGF, FGF, etc.).
This angiogenesis is a similar process to what we discussed in cancer lectures.