What is the role of hypercholesterolemia in the pathogenesis of atherosclerosis?
The higher the LDL concentration in the blood, the longer any given LDL molecule circulates before it is removed.
Blood is an oxidizing environment.
The longer LDL circulates, the greater the fraction of oxidized LDL.
LDL suppresses activity of TGF-beta which normally functions to protect vessels against injury.