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1. A Virus is a cell composed of genetic material.
F- NOT A CELL!
2. Viruses are obligate intracellular parasites.
3. All viruses possess both DNA and RNA.
F Either one or the other
4. Viruses are extracellular.
T- they must be intracellular to replicate only.
5. Virus envelopes are derived from viral proteins.
F- host cell proteins
6. All viruses have envelopes.
7. Virion and virus is interchangeable.
8. Empty capsids are able to replicate.
F. They are incomplete and are without chromosomes. The more inefficient a virus (more empty capsids) the more mild the virus is.
9. Pseudovirions are infectious.
F, Pseudotypes are infectious.
10. The majority of viruses multiply in the nucleus.
F- in the cytoplasm.
11. All viruses have a single capsid.
F- All BUT Reoviridae.
12. Capsomeres are solid in reo and herpes viruses but hollow in others.
F- hollow in herpes in reo and solid in others.
13. Every helical virus that causes disease in an animal has an envelope.
14. All viruses carry their own enzymes.
F- Not all but some.
15. Naked viruses tend to be more stable in the environment than enveloped viruses.
16. DNA viruses can never undergo genetic reassortment.
T- Only a few RNA viruses.
17. Retro virus is the exception to negative sense RNA viruses.
F, + sense. Although it is + it is not immediately infectious.
18. Acidic conditions lead only to irreversible disassembly of the viral capsid.
F- reversible or irreversible.
19. There are more DNA viruses than RNA viruses.
20. All viruses have inclusion bodies.
21. All pox viruses cause skin lesions and are oncogenic.
F- not all are oncogenic.
22. Only enveloped poxviruses are infectious.
F- Both enveloped and naked.
23. Monolayer plaque assays show colored necrotic plaques.
24. Capsids and chromosomes are generated separately.
25. Enveloped viruses are released by budding.
26. Only Naked viruses kill the cell.
F Some enveloped viruses do as well.
27. Most enveloped viruses get their membrane from the plasma cell membrane.
T Herpes gets it from the nuclear membrane. Some get them from the ER or Golgi, etc.
28. Latent viruses are active infections waiting to lyse cells and cause disease.
29. If a cell is not infected by a particular virus, you will not see inclusion bodies.
30. All nonenveloped naked animal viruses are helical.
31. Only helical mammalian viruses are enveloped.
F- some icosahedral viruses are also enveloped.
32. Naked viruses lyse the cells they inhabit.
33. Enveloped viruses bud from cell membranes.
34. Cell lysis is a more efficient mechanism of viral release.
F- Budding is more efficient