Pharm Chap 5
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What drugs can pass though the BBB?
Nonpolar lipid soluble drugs via passive diffusion
most abundant where?
- found in brain and periphery (skeletal NMJ and autonomic synapses)
- abundant in cerebral cortex
- originates in pyramidal cells of moter cortex and basal ganglia
- excitatory in nature
- Catecholamines (dopamine and norepinephrine)
Dopamine does what? (3)
regulates motor control, mood and emotion
Norepinephrine secreted by what?
overall effect is generally....
- locus caeruleus
- reticular formation
- excitation of brain, although involved in disinhibition
Serotonin released by? (2)
what does it do? (3)
- pons and brainstem
- 1. strong inhibitor of the CNS
- 2. Mediates inhibition of painful stimuli
- 3. helps control mood and behavior
Name two inhibitory.
Name two excitatory.
Glycine and GABA
Asparate and glutamate
name 2 peptides
- Supstance P-excitatory; transmits pain impulses
- endogenous opiods- endorphins, enkephalins, dynorphins; all excitatory in nature that inhibit painful sensations.
what amino acid decreases presynaptic action potential?
What drug blocks synthesis of NT?
What drug impairs the storage of NT?
Reserpine (antihypertensive drug)
Name a drug that impairs presynaptic reuptake of NT.
name a drugs that causes inhibition of NT degradation.
- ex: Anticholinesterase (inhibits Ach breakdown)
Presynaptic autoreceptor activation does what?
serves as negative feedback to control NT release
What does Presynaptic membrane alteration do?
alters fluidity of membrane to affect release of NT.
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