Pharm Chap 11
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Usually administered during extensive surgical procedures
Given when analgesia is needed in a relatively small, defined area.
Ideal Anesthetic, (6) conditions:
- Loss of consciousness and sensation
- Muscle relaxation
- inhibit sensory and autonomic reflexes
- minimal side effects
- rapid onset of anesthesia
Patient begins to lose somatic sensation, but is still aware
Stage I (Analgesia)
Unconsious, but appears agitated and restless. May trash about.
Stage II (Excitement/delirium)
Desirable for surgical procedure.
Onset of regular, deep respirations
Stage III (surgical anesthesia)
Cessation of spontaneous respiration
Stage IV (Medullary paralysis)
Name (6) inhaled anesthetics
- Desflurane (Suprane)
- Sevoflurane (Ultane)
- Enflurane (ethrane)
- Halothane (Fluothane)
- Isoflurane (Forane)
- Methoxyflurane (Penthrane)
Suprane-(faster onset and recovery, better control)
Ultane--(faster onset and recovery, better control)
Name (4) CNS depressants that can also serve as a general anesthetic (via intravenous)
- barbiturates- Thiopental and methohexital
- Benzodiazipines- Diazepam and lorazepam
- Opioid analgesics- Fentanyl, Meperidine and Morphine
- Ketamine- ketalar
Produces dissociative anesthesia
- (brevital sodium)
Drugs act as competivitve antagonists of the postsynaptic receptor.
Bind to receptor, but do not activate it.
- Depolarizing blocker
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