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Mechanism of Action
A serotonin receptor antagonist that prevents acute emesis by blocking serotonin receptors in the chemoreceptor triggering zone (CTZ) and afferent vagal neurons in the upper GI tract. It does not have prophylactic properties and therefore has no effect on delayed emesis. Does not cause extrapyramidal symptoms
Use cautiously with other drugs that prolong the QT interval
Headache, diarrhea, dizziness, fever, drowsiness, prolonged QT
May form precipitate with alkaline solutions
Dosage and Route
Adult: 4 mg slow IV/IM, may repeat once after 10 mins
Pedi: 0.1 mg/kg (max single dose 4 mg)
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