Immuno E2, III
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Routes in which a B Cell is activated by an antigen:
What kind of antigens can evoke immunological memory and class switching?
Th1 cytokines induce what type of Ab?
- Cell mediated Ab
- (IgG & IgM)
Th2 cytokines induce what type of Ab?
- Neutralizing Ab
- (IgE, IgA and some IgG)
Ab produced by Thymus-Induces Ag's:
If a P lacks CD40L on Th cells, only ___ is produced
____ is preserved during class switching
Variable Region, or Ag specificity
Class switching is driven by:
- Cytokines (Th1 vs Th2)
- Repitition (2' immune sys)
Class switching allows Ab to change function (not specificity) by...
switching to a different class
Phases of Primary Ab response:
What occurs during lag phase (3):
- Ag recognized by naive B cell
- B Cell proliferates & differentiates
- Makes Ab
Phases of 2' Ab response compared to 1' Ab response:
- Shorter Lag
- Rapid/Higher Log
- Long Decline (persists for months-life)
Major Ab class during 1'
IgM (doesn't persist)
Major Ab class during 2'
IgG, or IgA/IgE (DOES persist)
Ab responsible for blocking attachment of Ag
Ab responsible for Mast cell degranulation
Functions of Ab (6):
- Blocking of attachment
- mast Cell Degranulation
- ADCC (Ab dep cell cytotoxicity)
- Complement Activation
What do aggregations cause in vivo
Hypersensitivities or Immune Complex Dz
What can aggregations be used for in vitro?
What would you like to do?
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