Immuno E2, III

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  1. Routes in which a B Cell is activated by an antigen:
    • T-dependent
    • T independent
  2. What kind of antigens can evoke immunological memory and class switching?
    Thymus-Dependent
  3. Th1 cytokines induce what type of Ab?
    • Cell mediated Ab
    • (IgG & IgM)
  4. Th2 cytokines induce what type of Ab?
    • Neutralizing Ab
    • (IgE, IgA and some IgG)
  5. Ab produced by Thymus-Induces Ag's:
    • IgM
    • (very limited)
  6. If a P lacks CD40L on Th cells, only ___ is produced
    IgM
  7. ____ is preserved during class switching
    Variable Region, or Ag specificity
  8. Class switching is driven by:
    • Cytokines (Th1 vs Th2)
    • Repitition (2' immune sys)
  9. Class switching allows Ab to change function (not specificity) by...
    switching to a different class
  10. Phases of Primary Ab response:
    • lag
    • Log
    • Plateau
    • Decline
  11. What occurs during lag phase (3):
    • Ag recognized by naive B cell
    • B Cell proliferates & differentiates
    • Makes Ab
  12. Phases of 2' Ab response compared to 1' Ab response:
    • Shorter Lag
    • Rapid/Higher Log
    • Long Decline (persists for months-life)
  13. Major Ab class during 1'
    IgM (doesn't persist)
  14. Major Ab class during 2'
    IgG, or IgA/IgE (DOES persist)
  15. Ab responsible for blocking attachment of Ag
    IgE
  16. Ab responsible for Mast cell degranulation
    IgE
  17. Functions of Ab (6):
    • Opsonization
    • Neutralization
    • Blocking of attachment
    • mast Cell Degranulation
    • ADCC (Ab dep cell cytotoxicity)
    • Complement Activation
  18. What do aggregations cause in vivo
    Hypersensitivities or Immune Complex Dz
  19. What can aggregations be used for in vitro?
    Dx
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68988
Card Set
Immuno E2, III
Description
Immuno E2, III
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