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Functions of Complement Proteins:
- Ab/Non-Ab lysis
- Opsonization for phagocytosis
- Mast Cell Degranulation
- Clear immune complexes
Two pathways that activate the complement system
- Alternate/Natural Pathway
- Classical/Specific Pathway
The Alternate Pathway is also called...
- The lectin pathway
- (or Natural)
Which pathway is activated by the microbe alone?
Which pathway is activated by Ab?
Which pathway is AKA the Lectin Pathway?
What part of the Ab activates the Complement Protein C1?
Which classes of Ab trigger the Classical Pathway?
Which class of Ab is more efficient at triggering the Classical Pathway? Why?
IgM- Has closely spaced C' binding sites
The Classical Pathway reqires two Ig?
When does C1 bind to the Ab in the Classical pathway?
AFTER Ab binds to Ag
The ultimate task of the Complement Cascade is to form the ____, which leads to ____
- Membrane Attack Complex
- Cell Lysis
What are the end products of proteolysis and what happens to them?
- Small Protein- remains bound to complex at the surface of pathogen
- Peptide- diffuses away for other tasks (Mast Cell/Basophil degran and chemotaxis of neutrophils)
The complement system is effective in lysing (4):
- G- Bacteria
- Enveloped Viruses
How does Strep evade the Comp. System?
Capsule that prevents MAC insertion and C3b deposition
Bact can inactivate Comp. System via
How do some viruses evade the Comp. System?
They possess protiens that mimic regulatory proteins
How do Tumor Cells evade the Comp. System?
They can endocytose MAC and seal up the membrane