Immuno E2, VIII

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HLW
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69267
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Immuno E2, VIII
Updated:
2011-02-27 15:17:06
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Immuno
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Immuno E2, VIII
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  1. Which Hypersensivities are mediated by Ab's?
    • I
    • II
    • III
  2. Which Hypersensitivities are mediated by T-Cells?
    IV
  3. Response Time for Hypersensitivities I-IV
    • I: 2-30 mins
    • II: 5-8 Hr
    • III: 2-8 Hrs
    • IV: 24-72 Hrs
  4. What type induces a Cytolytic Response?
    Type II
  5. Which type induces the formation of Immune Complexes?
    Type III
  6. Which type is the DTH?
    Type IV
  7. Allergies and Atopy are caused by which type?
    Type I
  8. Allergy-
    Immediate, Type I, Hypersensitivity Rxn
  9. Atopy-
    Genetic predisposition to develop clinical Type I allergies
  10. Type I is mediated by
    • IgE
    • (which is attached to Mast cell)
  11. Normal response to environmental Ag's, involves the production of:
    IgG or IgA
  12. In a Type I response, IgE can bind to (3):
    • Mast Cell
    • Basophil
    • Eopsinophil
  13. What triggers a mast cells to degranulate in a type I?
    Cross-limking of 2 Ab's once an Ag is bound
  14. Degranulation of Mast Cells in a Type I =>
    • Histamine
    • Heparin
  15. Histamine ->
    • Smooth M contraction
    • Vasodilation
  16. Early Phase...
    Time:
    Symptoms (5):
    • Time:
    • 10-20 mins
    • Symptoms:
    • Vasodilation
    • Smooth Muscle Contraction
    • +/-Mucous Production
    • +/- Puritis
    • Wheel and Flare
  17. Late Phase...
    Time:
    Symptoms:
    • Time:
    • 6-12 hrs
    • Symptoms:
    • Redness
    • Edema
    • Pruritis
  18. Early Phase is mediated by:
    Histamine & Heparine from Mast Cells
  19. Late Phase is mediated by:
    Chemotactic Factors from Mast Cells that attract Eos and Neut's
  20. What=> Asthma
    Late Phase of Type I
  21. Severity of a Type I depends on...
    • Degree of sensitization
    • Amount of Ag involved
    • Route of admin
    • (= number and location of mast cells, eosinophils and basophils)
  22. Clinical Signs resulting from Anaphylaxis
    • Vasodilaton/Hypotension
    • Edema in shock organ
    • Hypovolemia
    • Smooth M Constriction/Bronchial Constriction
  23. Primary Shock Organ in Horses (2):
    • Lung
    • Intestine
  24. Primary Shock Organ in Ruminants:
    Pulmonary
  25. Primary Shock Organ in Dogs:
    Liver
  26. Symptoms Associated w/ anaphylactic shock in a dog:
    • Excitement
    • Vomiting
    • Defecation/Urination
    • Muscle weakness
    • Depressed RR
    • Blood pooling in GI and in Liver
  27. Primary Shock organ in Cats:
    Lungs
  28. Drugs/Haptenes become antigenic when...
    they bind to host proteins
  29. Urticaria-
    Skin rash consisting of red, edema, plaque-like eruptions, which are often pruritic
  30. Urticaria is most often observed in ___ & ___
    dogs and horses
  31. What causes urticaria?
    Inhaled or ingested antigens, drugs or insect bites
  32. Dx tests for Type-I (3):
    • Serum IgE
    • Measure IgE, specific to suspested allergen (intradermal tests)
  33. Tx for Type I:
    • Epinephrine (Norepi or dex SP in cattle)
    • Antihistamines
    • Corticosteroids
    • Anti-IgE Ab
    • Hyposensitization
  34. Hyposensitization works by...
    switching the Ab response away from IgE to IgG

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