Define bactericidal, bacteriostatic and bacteriolytic agents. Describe broad spectrum vs. narrow spectrum antibiotics and the advantages and disadvantages of each.
- bacteriocidal: “killing” the bact.
- bacteriostatic: stop bact from dividing (gentler on your flora than bacteriocidal; also lets your body see the bact and mount an immune response. CONS: if someone’s immunocompromised, they won’t be able to kill the bact)
- bacteriolytic: “lyses” bact. à makes them leaky
- broad spectrum Ab: Gram +/- CONS: Damages pt flora.
- narrow spectrum Ab: Gram – (like enteric bact after abdominal surgery). If you have myco. TB, you’ll get super narrow spectrum. CONS: if you give wrong abx, you’ve just allowed the real bact to grow one week more.
- A broad-spectrum antibacterial drug can inhibit a variety of gram-positive and gram-negative
- bacteria, whereas a narrow-spectrum drug is active only against a limited variety of bacteria.