are anticancer drugs that act on intermediary metabolism of proliferating cells
. (If they work on proliferating cells, then they must be CCS
- They take advantage of a number of quantitative differences in metabolism that exist between
- neoplastic cells and normal cells; these differences render tumor cells more susceptible to this particular class of anticancer drugs (the antimetabolites).
In other words, antimetabolites inhibit nucleic acid synthesi
s in the cell by competing with natural cofactors in the cell
. Therefore, antimetabolites are structurally related to intermediate cofactors in the cell
. The end result is antimetabolites inhibit DNA and RNA