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Where does NE come from?
Released by sympathetic post-ganglionic neurons
Where does Epi come from?
Secreted in to circulation by the adrenal medulla
Which nervous system (Sympathetic/PNS) are adrenergic receptors found?
What activates the adrenergic receptors?
NE and NorEpi (Catecholamines)
What are the different types of adrenergic receptors?
alpha 1 and 2, beta 1 and 2
Which adrenergic receptors have the same mechanism of action but different physiological effects?
B1 , 2 and 3
What are the different types of cholinergic receptors?
Nicotinic and muscarinic
Where are nicotinic receptors found?
In the motor end plate of skeletal m. and on all postganglionic neurons of the sympathetic and PNS as well as the chromatin cells of the adrenal medulla.
Where is Ach released from?
Motor neurons and all preganglionic neurons
Where are muscarinic receptors found?
In all effector organs of the PNS: heart, GIT, bronchioles, bladder and sex organs. Some are also found in the effector organs of the sympathetic
What is the mechanism of action of alpha 1 receptors?
Increase in intracellular Ca2+
What is the MOA of alpha 2 receptors?
Decreased CAMP, inhibition of adenylate cyclase
What is the MOA of beta receptors?
Stimulation of adenylate cyclase, increase in CAMP
What do Beta 1 receptors target?
- salivary glands,
- adipose tissue,
- and kidney
What do Beta 2 receptors target?
- Vasc. smooth m. of skeletal m.,
- GIT wall,
- Baldder wall,
- and bronchioles
What do alpha 1 receptors target?
- vascular smooth m,
- GIT sphincters,
- bladder sphincter,
- radial mm. of the iris
What do alpha 2 receptors target?
- GIT wall,
- presynaptic adrenergic receptors
What do Nicotinic receptors target?
- Skeletal m. at the motor end plate
- PNS and SNS postganglionic neurons
- adrenal medulla
What do muscarinic receptors target?
- All effector organs of the PNS
- Sweat glands of the SNS
What is the MOA of nicotinic receptors?
Depolarization via the opening of Na+ and K+ channels
What is the MOA of Muscarinic receptors?
Increase intracellular Ca2+