sensitize bronchial smooth muscl eto be more response to beta agonist stimulation --> corticosteroids aren't brochodilators, but they interact with beta agonists to cause more bronchodilation than beta agonists alone
name 3 leukotriene antagonists and frequency
zafirlukast [Accolate] - BID
zileuton [Zyflo] - QID
monteleukast [Singulair] - qday
what are leukotrienes?
what kinds of cells produce them?
mediators of immune and inflammtory responses; products of arachidonic acid breakdown
administration route of leukotriene antagonists?
how should it be taken in relation to meal times?
take on empty stomach b/c food decreases bioavailability of drug
are leukotrienes used for treating acute asthma attacks?
no! prophylaxis only
how do leukotrienes antagonists indirectly cause bronchodilation?
inhibiting leukotriene's normal FX (via receptor antagonism): promotion of inflammation, edema, and hypersecretion of mucus
zafirlukast [Accolate] drug interactions
coumadin: increases PT (anticoagulates)
erythromycin: decreases Accolate
ASA: ^ Accolate
also interacts with phenytoin and CBBs, increasing their concentrations