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Name the parts of this bone:
What is Fibrodysplasia Ossificans Progessiva (FOP)?
- –Disease that occurs
- when lymphocytes produce BMP-4 protein
- •This is a protein
- that triggers bone formation
How does Bone
- –1-physical action of
- muscles pulling on bones stimulates osteoblasts-building bone
–2- release of calcitonin which inhibits osteoclast activity
Name the classification of bones and an example of each.
- 1. Long bones - femur
- 2. Short bones - carpals & tarsals
- 3. Irregular - vertebrae - sacrum
- 4. Flat - scapula
- 5. Sesmoid - patella
What are the 2 types of bone categories?
- 1. Compact bone - 80%
- 2. Spongy bone - short, flat, irregular bones - epiphysis of long bones
Describe Intramembranous Ossification
- 1. Sheets of messenchyme tissue - osteoblasts form and start making bone tissue, they group together to secrete bone matrix.
- 2. Ca+ is deposited into the matrix and calcification begins - forming spikes called trabiculae.
- 3. The trapped osteoblasts become osteocytes
- 4. Trabeculae fuse together to become spongy bone.
Flat bones, facial bones, sternum are made this way.
Describe Endochondral Ossification
- 1. Messenchyme cells gather in shape of future bone
- 2. Chondroblasts - move into the messenchyme & begin forming cartilage in the shape of the future bone
- 3. Starts in diaphysis - chondrocytes grow and burst changing the pH of matrix - which begins to harden - forming bone.
- 4. As cartilage disintegrates bone is formed solid so osteoclasts move in to hollow out the center
- 5. At the same time the outer edge of bone model - osteoblasts are forming bone
- 6. In the epiphysis - osteoblasts invade cartilage on the end and begin forming trabeculae which forms spongy bone.
Osteoperosis results from
too much osteoclast activity
What happens when there is too much Ca++ in the ECF?
- Calcitonin (CTH) increases osteoblast activity and inhibits osteoclast activity - PTH is inhibited
- Ca++ is deposited into skeletal system
What happens when there is not enough Ca++ in the ECF
Thyroid secretes Parathyroid Hormone (PTH) increasing osteoclasts - ultimately increasing Ca++ in ECF
Regulation of growth
• Growth Hormone Releasing Hormone (GHRH) to the:
• anterior pituitary-which releases:
• GH-growth hormone
•The level of growth hormone can result in disease.
• Pre-growth plate closure
- –Dec GH=Dwarfism
- –Inc GH=Gigantism
- • Post growth plate closure
- Inc GH=Acromegaly
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