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Heme synthesis occurs where in the cell?
What 3 processes take place in mitochondria and cytosol?
Acute porphyria usually manisfest how?
Cutaneous type of porphyria manifests how?
In heme metabolism enzyme deficiency, if a deficiency of enzyme occurs after the formation of porphyrinogen, what types of symtoms are present?
If an enzyme is deficient before the formation of porphyrinogen, what types of symptoms are present?
Which porphyrins are of physiological importance?
Lead inhibits which enzyme involved in the synthesis of heme?
What is the rate determining enzyme in heme synthesis?
ALA synthase I is present where?
ALA synthase II is present where?
What are two allosteric inhibitors of ALA synthase?
What inhibits the translation of ALAS 1?
In bone marrow, what controls the synthesis of heme?
Why would ingestion of drugs stimulate the synthesis of heme in the liver?
bc cytochrome p 450 needs heme
cyt p 450 is used to metabolize drugs
What is the consequence of irradiating porphyrins?
they form free radicals
X linked sideroblastic anemia affects which ALA synthase?
Which heme synthesis disorders produce cutaneous as well as acute symptoms?