Inside cells N5
methyltetrahydrofolate is converted to THF
by vitamin B12 dependent demethylation reaction. What is THF?
THF is tetrahydrofolate, and it requires cobalamin in order to convert the dietary folates that were converted to N5 methyltetrahydrofolate to tetrahydrofolate, which is used to convert serine into glycine. This is 1 of 4 reactions that require THF cofactors to participate in one-carbon transfer reactions.