"Opathies" in Diabetes

Card Set Information

Author:
giddyupp
ID:
70596
Filename:
"Opathies" in Diabetes
Updated:
2011-03-03 23:27:53
Tags:
\"Opathies\" Diabetes PHPR523 Test4
Folders:

Description:
"Opathies" in Diabetes
Show Answers:

Home > Flashcards > Print Preview

The flashcards below were created by user giddyupp on FreezingBlue Flashcards. What would you like to do?


  1. What is the appropriate screening for nephropathy in diabetes?
    • Annual testing for microalbuminuria starting at diagnosis for Type II, 5yrs after diagnosis for Type I
    • Annual Scr
  2. What is the appropriate screening for neuropathy in diabetes?
    • 10 guage monofilament test in 4 spots
    • Annual diabetic foot exam
  3. What is the appropriate screening for retinopathy in diabetes?
    Annual ophthalmic exam until stable, then q 2-3yrs
  4. What is the tx for nephropathy?
    • ACEI
    • ARB
    • Non-dihydropyridine CCBs (Diltiazem, Verapamil), BBL, or diuretic
    • + Protein restriction (0.8-1.0g/kg or less)
    • + Replace red meat with chicken
    • Dialysis
  5. What is the tx for neuropathy in diabetes?
    • TCA
    • Carbamazepine
    • Valproate
    • Pregabalin
    • Duloxetine
  6. What is the tx for autonomic neuropathy in diabetes?
    • Metoclopramide
    • Erythromycin
    • PDE-5 inhibitors (ED)
    • Intraurethral prostaglandins (ED)
    • Vacuum devices (ED)
    • Avoid diets high in fiber
    • Multiple small meals throughout the day
    • moderate exercise
  7. What is the tx for retinopathy in diabetes?
    None that work besides glycemic and BP control
  8. What are the SE of ACEI?
    • Cough
    • Angioedema
    • Hyperkalemia
    • Renal toxicity
  9. What are the SE of ARBs?
    • Cough (much less than ACEI)
    • Angioedema (much less than ACEI)
    • Hyperkalemia
    • Renal toxicity
  10. What are the SE of TCAs?
    • Anticholinergic SE (anti-SLUD - salivation, lacrimation, urination, defecation)
    • Sedation
    • Wt gain
    • Alpha blockade
    • QT prolongation
    • Torsades de pointes
  11. What are the SE of Carbamazepine?
    • Aplastic anemia
    • Dizziness
    • Auto-induction
    • 3A4 induction
  12. What are the SE of Valproate?
    • Wt gain
    • Tremor
    • Alopecia
    • Increased LFTs
    • Increased ammonia
    • Loss of libido
    • Pancreatitis
  13. What are the SE of Pregabaliln?
    • Dizziness
    • Sedation
    • Blurred vision
    • Wt gain
    • Discontinuation syndrome
    • Renal issues (adjust for dysfunction)
  14. What are the SE of Duloxetine?
    • Nausea
    • Constipation
    • Diarrhea
    • Dry mouth
    • Fatigue
    • HA
    • Discontinuation syndrome
    • $$$$$$$
  15. What are the SE of Metoclopromide?
    • Facial spasms
    • Depression
    • EPSE including irreversible tardive dyskinesia
  16. What are the SE of Erythromycin?
    • Skin rash
    • Cramping
    • N
    • Abdominal pain
    • Sudden cardiac arrest (QT prolongation)
  17. How do ACEI protect against nephropathy?
    dilation of efferent arteriole = decreased pressure in glomerulus = decreased protein in urine = decreased progression of kidney disease
  18. How do CCBs protect against neuropathy?
    • vasodilation
    • decreased HR
    • negative inotrope
    • (decreased CO overall)
  19. How do TCAs help protect against neuropathy?
    slow the nerve conduction = decreased pain
  20. How does pregabalin protect against neuropathy?
    • unknown
    • binds with high affinity to the alpha2-delta site in CNS tissues
    • decrease in Ca dependent release of several neurotransmitters is seen in vitro
  21. How does Duloxetine protect against neuropathy?
    potent inhibitor of neuronal 5-HT and NE reuptake and a weak DA reuptake inhibitor
  22. What is the MOA of Metoclopramide in gastroparesis?
    • 5-HT4 agonist
    • 5-HT3 antagonist
    • D2 antagonist
    • Cholinergic facilitator
  23. Wht is the MOA of Erythromycin in gastroparesis?
    Motilin receptor agonist

What would you like to do?

Home > Flashcards > Print Preview