Card Set Information
Thyroid Disorders PHPR523 Test4
What are the sx of hypothyroidism?
Wt gain (despite decreased appetite)
Increased cholesterol and TG
Decreased deep tendon reflexes
What are the sx of hyperthyroidism?
Increased bowel movements
Warm skin, excess sweating
Nervousness, emotional lability
Fine, thin hair
Wt loss (despite increased appetite)
What are the trends for lab values in hyperthyroid disease?
What are the trends for lab values in hypothyroid disease?
What is the normal range of TSH?
What is the normal range for Free T4?
What is the normal range for Total T4?
What is the normal range for Total T3?
What is the dosing for Levothyroxine?
50mcg x 1mo, then 100mcg
25mcg x 1mo, titrate by 25mcg (Elderly)
Normal maintenance dose = 1.7 mcg/kg/d
How should Levothyroxine be administered?
On an empty stomach 30min before or 1h after the 1st meal of the day
separate from calcium, iron, and caffeine by 2hrs
How should Levothyroxine be monitored?
TSH and T4 q 6wks after initiation
Goal TSH is 0.5-3.5 mIU/mL
What are the disadvantages of T3?
Higher risk of cardiotoxicity
What are the SE of Levothyroxine?
Increased fracture risk
What is subclinical hypothyroidism?
Normal T4 with elevated TSH
Treat if TSH > 10 mIU/mL
What medications might interact with levothyroxine or thyroid disorder?
disorder causes slower clotting factor metabolism (need more warfarin)
levothyroxine causes decreased drug metabolism (need less warfarin)
What medications can cause hypothyroidism?
What are the sx of a myxedema coma?
How do you treat myxedema?
T3 or Combo
What is the tx for hyperthyroidism?
What are the SE of MMI and PTU?
Altered smell (MMI)
What is the adjunct therapy for hyperthyroidism sx?
Propranolol (blocks T4 conversion to T3)