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What is the equation for GFR?

What is the equation for Creatinine Clearance?

What is the equation for Dosing Rate?

Time for plasma concentration of drug to be reduced by 50%
Halflife

When the ellimination of a drug = availability
 Steady state
 it takes 45 halflives to reach this

Fraction of the drug that enters systemic circulation (Bword)
Bioavailabilty

Giving a big dose in the beginning to reach therepeuttic window faster
Loading dose

What is the equation for Loading Dose?
 LD: Loading Dose
 Target Cp: Target plasma concentration
 Vss: Volume of distribution in steady state
 F: Bioavailability

What is the equation for Maintenance Dose?
 MD = Target C_{p} x CL / F
 MD: Maintenance dose
 Target Cp: Target plasma conc
 CL: clearance
 F: Bioavailability

