GE15
Card Set Information
Author:
Bobopudge
ID:
70677
Filename:
GE15
Updated:
2011-03-27 11:55:04
Tags:
GE Kidney Drug elimination Kevin
Folders:
Description:
Drug Elemination
Show Answers:
What is the equation for GFR?
What is the equation for Creatinine Clearance?
What is the equation for
Dosing Rate
?
Time for plasma concentration of drug to be reduced by 50%
Half-life
When the ellimination of a drug = availability
Steady state
it takes 4-5 half-lives to reach this
Fraction of the drug that enters systemic circulation (
B-word
)
Bioavailabilty
Giving a big dose in the beginning to reach therepeuttic window faster
Loading dose
What is the equation for
Loading Dose
?
LD
: Loading Dose
Target Cp
: Target plasma concentration
Vss
: Volume of distribution in steady state
F
: Bioavailability
What is the equation for
Maintenance Dose
?
MD = Target C
_{p}
x CL / F
MD
: Maintenance dose
Target Cp
: Target plasma conc
CL
: clearance
F
: Bioavailability