GE15

Card Set Information

Author:
Bobopudge
ID:
70677
Filename:
GE15
Updated:
2011-03-27 11:55:04
Tags:
GE Kidney Drug elimination Kevin
Folders:

Description:
Drug Elemination
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  1. What is the equation for GFR?
  2. What is the equation for Creatinine Clearance?
  3. What is the equation for Dosing Rate?
  4. Time for plasma concentration of drug to be reduced by 50%
    Half-life
  5. When the ellimination of a drug = availability
    • Steady state
    • it takes 4-5 half-lives to reach this
  6. Fraction of the drug that enters systemic circulation (B-word)
    Bioavailabilty
  7. Giving a big dose in the beginning to reach therepeuttic window faster
    Loading dose
  8. What is the equation for Loading Dose?
    • LD: Loading Dose
    • Target Cp: Target plasma concentration
    • Vss: Volume of distribution in steady state
    • F: Bioavailability
  9. What is the equation for Maintenance Dose?
    • MD = Target Cp x CL / F
    • MD: Maintenance dose
    • Target Cp: Target plasma conc
    • CL: clearance
    • F: Bioavailability

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