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factors that influence mean arteriole pressure
- blood volume
- effectivness of heart as a pump
- resistance of system
- distribution of fluid between arteries and veins
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blood flow
inversly related to change in pressure / resistance
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vasoconstriction caused by
myogenic activity, oxygen, carbon dioxide, endothelin, sympathetic stimulation, vasopressin, angiotensin2, and the cold
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vasodialation caused by:
decreased myogenic activity oxygen, carbon dioxide, decreased sympathetic stimulation, histamine release, and heat.
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pulse pressure determined by
- stroke volume
- distensability of vessels
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filtration is caused by
hydrostatic pressure
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blood flow is determined by
a vessels resistance to flow
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disruption between the balance of filtration and absorption causes
- increase in hydrostatic pressure
- decrease in plasma proteins
- increase in interstitial fluids
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The baroreceptor reflex: the response to orthostatic hypotension
- increased blood pressure
- parasympathetic only effects SA node
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The baroreceptor reflex: response to orthostatic hyper tension
- decreased blood pressure
- parasympathetic only effects the SA
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symptoms of hyper tension
- headaches
- blurred vision
- fatigue
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facts of hypertension
- occurs in 35-50% of people (50% get end organ developement)
- shortens life by 10-20 years
- HTN risk doubles with every 20/10 increase in mmhg
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secondary hypertension
- secondary to a disease
- nephrosclerosis is most common (3-5%)
- hyper aldosterone increased blood volume
- pheochromocytoma catecholamine secreting tumour
- 5-10% causes renal disease
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Risk factor for atherosclerosis
- • Heart muscle hypertrophies
- • Pulmonary edema (build up of fluid)
- • Congestive heart failure
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pressures associated with hypertension
- wide pulse pressure: systolic
- TPR: diastolic
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treatment of hypertension
- Calcium channel blockers
- Diuretics
- Betablocking drugs
- ACE inhibitors
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OTHER types of hypertension
- - malignant hypertension
- - hypertension associated to pregnancy
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