Top 200: Muscle Relaxants, Alzheimers & Headaches
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80 million Americans are victims of chronic pain
Many patients take muscle relaxant medications to help aid in pain management
Relax striated muscles
What type of disease states or conditions are muscle relaxants used for?
- Skeletal muscle relaxants may be used for relief of spasticity in neuromuscular diseases, such as:
- - multiple sclerosis
- - spinal cord injury
- - stroke
Also used for pain relief in minor strain injuries
What are the muscle relaxants?
What is Alzheimer's?
Progressive brain disorder
Most common form of dementia
Destroys brain cells
- - Memory
- - Ability to learn
- - Reason
- - Judgment
- - Communication skills
- - Ability to carry out normal daily functions
Can Alzheimer's be prevented or cured?
- Alzheimers cannot be cured
- Questionable as to whether it can be prevented
What is the progression of Alzheimer's?
Advances at different rates: ranges from 3-20 years
Eventually complete loss of brain function will occur, eventually causing death
Memory loss is the hallmark of Alzheimer's disease
Early stages: minimal help
Late stages: help with normal daily functions
What are the treatment options for Alzheimer's?
- Cholinesterase Inhibitors: increase levels of acetylcholine
- - Aricept
- - Exelon
- - Razadyne
- Uncompetitive low-to-moderate affinity N-methyl-D-aspartate (NMDA) receptor antagonist
- - Namenda
How long do medications for Alzheimer's take to start working?
Medications are usually tritrated after 4 to 6 weeks.
What are possible causes of headaches?
- Eye strain
- Tension/stress induced
- Brain tumors
- Head injury
- Medication induced
- Caffeine withdrawal
- Food triggers
- Environmental triggers
What symptom may or may not accompany migraines?
Migraines may or may not have auras
associated with them.
What are the five types of headaches
- Vascular (cluster or migraine)
- Muscular (tension)
- Cervicogenic (neck disorder)
- Traction (eye strain)
- Inflammatory (sinusitis)
What are possible treatments for headache?
Lower your body temperature
- - NSAIDS
- - Triptans
- - BP meds
- - Antidepressants
- - Muscle Relaxers
What is the first line of treatment for patients with moderate to severe migraines?
What are Triptan Medications?
Serotonin receptor agonists (activate 5-HT1B and 5-HT1D)
What amino acid are Triptan drugs based upon?
Triptans are a family of tryptamine-based drugs
used as abortive medication
in the treatment of migraines and cluster headaches
According to Wikipedia, Tryptamine is a monoamine alkaloid
found in plants, fungi, and animals. It is based around the indole ring structure
, and is chemically related to the amino acid tryptophan
, from which its name is derived.
Tryptamine is found in trace amounts in the brains
of mammals and is believed to play a role as a neuromodulator or neurotransmitter
What are Triptan medications used for?
Treatment of migraine and cluster headaches.
What is the mechanism of action of Triptan drugs?
- Bind to serotonin receptors in the brain.
- Inhibition of pro-inflammatory neuropeptide release.
What are the five Triptan drugs?
What are the oral and nasal dosing recommendations for Imitrex?
Oral: A single dose of 25 mg, 50 mg, or 100 mg (taken with fluids). If a satisfactory response has not been obtained at 2 hours, a second dose may be administered. Results from clinical trials show that initial doses of 50 mg and 100 mg are more effective than doses of 25 mg, and that 100 mg doses do not provide a greater effect than 50 mg and may have increased incidence of side effects. Although doses of up to 300 mg/day have been studied, the total daily dose should not exceed 200 mg.
Intranasal: A single dose of 5 mg, 10 mg, or 20 mg administered in one nostril. A 10 mg dose may be achieved by administering a single 5 mg dose in each nostril. If headache returns, the dose may be repeated once after 2 hours, not to exceed a total daily dose of 40 mg.
- Muscle Relaxants:
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