Card Set Information
antibacterial drugs pg 115-121
t/f antibiotics are given before a tooth is worked on to get rid of the infection
FALSE! do treatment and then if infection doesn't reslove give antibiotics
Antibiotics are used in dentistry to treat ______ infection
how long must you premed for a joint replacement?
as a dental hygienist what is our role in antibacterial therapy? 4
why drug is used
follow up on pt compliance
what is it called when the normal flor becomes pathogenic
what is it called when there is a proliferation of transient microoganisms?
t/f autogenous infections occur when there is a proliferation of transient microorganisms
FALSE! Autogenious infections is when the normal flor becomes pathogenic (the other is a cross infection)
the common thread in pharmacologic strategies is to target differences between _______, (bacterial) and _____ (host or body) cells.
t/f eukaryotic cells are bacterial cells
FALSE! Host or Body cells eUkaryotic cells its all U!
are prokaryotic cells bacterial or host cells?
what is a unique target for antibacterial thearpy? why doesn't this effect the host cells?
bacterial cell wall
because human cells don't have cell walls
what are the three rules for antibacterial drug selection
Remove infectious debris and allow host immune response to be initiated
select agent to which infecting organism is susceptible
select agent that is the most narrow spectrum
by the time antibacterial agnets are indicated what is seen in the host? (signs for giving antibiotics)
t/f gram - bacilli predominate during infection
what is described: reduction of number of normal flora, broad spectrum cause opportunistic infection, non susceptible microbes flourish
t/f you want to pick the most broad spectrum drug to fight infection
FALSE! narrow spectrum
t/f bactericidal drugs slow the growth of bacteria
FALSE! they kill bacteria, bacteriCIDAL like suiCIDAL=death
is it bacyericidal or bacteriostatic if it slows the growth of bacteria
what is it called when larger amounts of antibiotic are given to get a higher blood level all at once
t/f oral infections are all gram positive
FALSE poly microbial (caused by gram + and gram -)
is a granuloma chronic or acute
CHRONIC (anything with bone being eaten is chronic)
a chonic infection is more _____ for the anaerobes
with a chronic infection bacterial species ____ and selective ______ survive
with a chronic infection the microbiology is more ____ than acute
t/f chronic infections are poorly localized
FALSE! chronic infections are localized
successfull treatment of an infection is based on the debridement and the _______ immune system
if you have an immunocompromised pt what is used along with the debridement to treat infection?
if the ______ function is suppressed it can adversely affect the therapeutic outcome, they can be adversely affect by a variety of diseases and by meds such as _______ therapy
with a reduced immune response a ______ antibiotic may need to be used instead of a ______
what are some examples of bactericidal drugs?
what is the action of a bactericidal drug?
interrupt cell wall synthesis during cell division
what drug is a DNA synthesis inhbitor in aneorbes?
what are some examples of bacteriostatic drugs
t/f immunocompetent hosts need to have bacteriocidal drugs and immunocompromised need bacteriostatic drugs
bacterial cell wall inhibitors that are the most important are ______ and _____-______
what are the drugs of choice for antibacterial prophylaxis
what is recommended if a beta-lactam allergy exists?
clindamycin or macrolide antibiotics (azithromycin, clarithromycin)
what is the prototype for the penicillin class?
how is penicillin G administered?
what was the first oral doseform of penicillin?
what is the most common agent used today for penicillins?
what was added to penicillin to enhance absorption?
t/f penicillin VK is bactericidal
what iss associated with a non allergic rash with pt with mononucleosis
what is the most commonly prescribed anitbacterial drug in dentistry
t/f penicillin is safe to give to pregnant women
true class B
amoxicillin + _____ ______ = augmentin
what is added to some penicillins to make resistant to penicillinase?
what is the prototype penicillinase resistant agent?
what is used when an organism releases penicillinase and degrades penicilllin molecules
penicillinase resistant agents
what antibiotic prophylaxis is used for a pt with TJR
t/f cephalexin is a first line agent used for antibiotic prophylaxis for individulas with TJR
Cephalosporins are structurally related to _____
what drug is used for periodontal infection (gram negative)
metronidazole is effective against _____ _____
are the inhibitors of transcription or trnaslation of RNA bacteriostatic or bacteriocidal?
what binds to the 50S ribosomal subunit?
Macrolids-erythromycin CLARITHROMYCIN, AZITHROMYCIN and LINCOSAMIDES (CLINDAMYCIN)
what are the agents that bind to 30S ribosomal subunit
aminoglycosides-gentamycin, neomycin, streptomycin
all of the following antibacterial agents are condsidered bacteriostatic except:
E. cephalosporin (beta-lactam)
(this multiple choice question has been scrambled)
what are the three explanations for biofilms resistance to antibacterial agetns?
slow and incomplete penetration of antibacterial agents into bifolm
altered chemical microenviroment
low metabolic state
t/f the bacteria are more susceptible to antibiotics when they are in their planktonic form rather than in biofilm
once in biofilm bacteria are protected against _____ by PNMS (neutrophils)
biofilm drug resistance is related to the slow and _____ penetration of ______ agents into biofilm
when taking the antibiotics you should instruct the pt to take agent ____ minutes before or ____ hours after a meal
what foods should tetracycline not be taken with?
calcium containing foods
why shouldn't tetracycline be taken with calcium?
it binds to it and inhibits from working
t/f amoxicillin, pen VK, metronidazole, azithromycin and clindamycin are affected by food
FALSE are NOT affected by food
which of the following antibacterial agents is structurally realted to penicillin?
(this multiple choice question has been scrambled)
is aminioglycocides baceriostatic or bacteriocidal?
is cephalosporins bacteriocidal or bacteriostatic?
is erythromycin bacteriostatic or bacteriocidal?
is metronidazole bacteriocidal or bacteriostatic
is tetrcycline bacteriostatic or bacteriocidal
t/f erythromycin is a macrolide?
t/f cephalosporins is a beta lactam and is structurally realated to penicillin