ch 10 pharm
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t/f fungal infections are common after antibiotic or steroid use in an immunocompromised patient
Nizoral (ketocanazole) are all what kind of agents?
what antifungal members of the soil microbial flora have the ability to live on decaying organic matter?
Saprophytic ("Sap" on the tree fell on the "soil")
_________ are the most common organisms associated with human disease
what is caused by a fungi or mold?
mycotic infection (MY COT was covered in FUNGI and MOLD when i took it out of the garage after 15 years)
what infection is opportunistic (able to spread quickly) in nature?
what is the MOST common FUNGAL INFECTION seen in a dental office?
CANDIDIA ALBICANS (thrush, candidiasis)
what are three conditions that are primarily responsible for mycotic infection?
-Increased use of therapeutic immunosuppression drugs for organ transplantation
-tx of malignant diseases
what is opportunistic
has complex pharmacologic tx
subacute in nature
and has a relapse tendency?
what is a disease dev without overt clinical signs and symptoms?
what does HSV stand for?
herpes simplex virus
what does HIVD stand for?
human immunodeficiency viral disease
a neonate is an infant younger than ___ _____ of age
what is the evolution from commensal (commen over I wont harm you) status to causing disease called?
an agent that lives in an environment without causing harm is called:
commensal agents ("commen" over don't be shy, i wont harm you)
what kind of therapy inhibits ERGOSTEROL SYNTHESIS (hint: kills fungi)????
what disrupts fungal plasma by dividing to form ergosterol?
what is ergosterol necessary for?
cellular activity (when synthesized within fungal cells from Acetyl CoA)
what inhibits DNA synthesis as well as microtubule function?
how do the antifungal agents used in dentistry act, by which 2 mechanisms?
inhibits ergosterol synthesis
disrupts fungal plasma from dividing to form ergosterol
which antifungal agents inhibit ergosterol synthesis? (hint:
"you azole! you inhibited ergosterol!")
Lotrimin/Myclex aka _________ is the #1 drug used for ______ ________ synthesis
Ketoconazole = _________
Nizoral (drug interactions)
Itraconazole = _______
what is the #2 drug used to inhibit ergosterol synthesis?
Fluconazole (FLU #2)
Fluconazole = ________
Diflucan (I will DI if I get the FLU before I can get to the CAN to go #2)
what is the #1 tx for candidiasis (thrush)?
Nystatin (it will get rid of the candidiasis stat!)
is there a risk for drug interaction when taking Nystatin?
no, no there is not
what are two ergosterol BINDING drugs? (2)
t/f azoles are not entirely selective for fungal enzymes
T/F there are no drug interactions for Azoles
FALSE!!! there are MANY drug-drug interactions
what is a major adverse effect of Azoles?
what is the #1 Drug used to inhibit ergosterol synthesis?
Clotrimazole (Lotrimin/Mycelex) no one will "trim" you a new "azole", you are already #1!
how should Clotrimazole troche be taken? how many times/day?
it is a lozenge that is to be dissolved in the mouth 5X/day
what will interact with heart meds?
ch 10 pharm
ch 10 pharm (love notes) including keywords