An aerosol is suspension of liquid or solid particles in a gas.
Defined as the mass or fluid or drug contained in aerosol produced by nebulizer.
Is the mass of aerosol generated per unit of time. Varies by diff neb and inhalers.
Described the mass of drug leaving the mouthpiece as a aerosol.
Fraction of inhaled dose deposited in the lungs.
What do most nebs in RC produce? what aerosol?
Different kind of deposition?
1. Interial impaction
Occurs when aerosol in motion collides with a surface (greater than 5-10 um) (oro/hypopharynx)
Occurs when aerosol particles settle out (1-5 um) of suspension and are depsoited due to gravity. Small particles represent primary for deposition. Increases w/ breath holding. The greater the mass of particle, the faster it will settle.
Very small particles (.5-1 um) Stay suspended in lungs and exhaled back into the environment.