Drugs Group 10

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Author:
oteff
ID:
71403
Filename:
Drugs Group 10
Updated:
2011-03-07 18:32:51
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Drugs Group
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Drugs Group 10
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  1. PRALIDOXIME CHLORIDE (PROTOPAM, 2-PAM)
    Class:
    Antidote for selected chemical warfare agents and organophosphateexposures
  2. PRALIDOXIME CHLORIDE (PROTOPAM, 2-PAM)
    Mechanism of Action:
    Reactivates cholinesterase that has not irreversibly“aged”. The average aging time varies from minutes withsome military nerve agents to a few days with someorganophosphate pesticides
  3. PRALIDOXIME CHLORIDE (PROTOPAM, 2-PAM)
    Indications:
    Organophosphate pesticide or military nerve agent poisoning,Unknown cholinesterase inhibitor poisoning
  4. PRALIDOXIME CHLORIDE (PROTOPAM, 2-PAM)
    Contraindications:
    • Absolute: Inability to perform endotracheal intubation (ifneuromuscular blockage were to occur – a rare,dose and rate related complication)
    • Relative: Myasthenia gravis, renal failure
  5. PRALIDOXIME CHLORIDE (PROTOPAM, 2-PAM)
    Dosage:
    • Adult: 1–2 g IV over 5-10 min. This dose may be repeated 1 hr after thefirst, if weakness or fasciculation have not resolved. 500 mg/hrcontinuous IV infusion for 24 hr after initial bolus
    • Pediatric: 20–40 mg / kg IV over 10 min. 5–10 mg/kg/hr continuous IVinfusion for 24 hr after the initial bolus
  6. OXYTOCIN (PITOCIN)
    Class:
    Hormone
  7. OXYTOCIN (PITOCIN)
    Mechanism of Action:
    Oxytocin indirectly stimulates contraction of uterine smooth muscle by increasing the sodium permeability of uterine myofibrils. Produces intense uterine contractions
  8. OXYTOCIN (PITOCIN)
    Indications:
    Postpartum bleeding after expulsion of the placenta
  9. OXYTOCIN (PITOCIN)
    Contraindications:
    Any condition other than postpartum bleeding
  10. OXYTOCIN (PITOCIN)
    Precautions:
    Absence of additional fetuses (twins/triplets) must be establishedand placenta must be delivered prior to administration. Overdose can cause uterine rupture.
  11. OXYTOCIN (PITOCIN)
    Dosage
    10-40 units in 1,000 ml titrated to uterine response (ideally infused at arate of 20–40 milliunits/min), or 10 units IM

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