immuno #1.txt

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Author:
kepling
ID:
71428
Filename:
immuno #1.txt
Updated:
2011-03-22 14:11:26
Tags:
immuno
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immuno #1
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  1. Name the five WBC
    • 1) Neutrophils
    • 2) Lymphocytes
    • 3) Monocytes
    • 4) Eiosinophils
    • 5) Basophils
  2. What are the two lineages of Hematopoietic stem cells (HSC's)?
    • Myeloid: Macrophages, Granulocytes, RBC, platelets
    • Lymphoid: T-cells, B-cells, NK cells
  3. What are three important cytokines?
    • IL-3
    • IL-7
    • GM-CSF
  4. What does IL-3 and IL-7 form?
    Lymphoid stem cells
  5. What does IL-3 + GM-CSF form?
    Myeloid line
  6. What is the difference b/t inducible and constituitive hematopoiesis?
    • Inducible: ramp up production due to injury
    • Constituitive: Constant production
  7. What CD is crucial for bone marrow transplants?
    CD 34+
  8. How does antigen presentation work?
    • -Phagocytose protein
    • -Break down protein and expose antigen on surface of cell
  9. What is necessary for activation of T-cells?
    Antigen presentation (APCs)
  10. What molecules display antigens on cells?
    MHCs
  11. What four cells utilize APC?
    • Monocyte
    • Macrophage
    • B-lymphocyte
    • dendritic cell
  12. What are two common dendritic cells and where are they found?
    • 1) Langerhan: Epidermis
    • 3) Interstitial: Organs/tissues
  13. What are the three granulocytes?
    • Neutrophils
    • Eiosinophils
    • Basophils
  14. What does left shift mean?
    When there are immature Neutrophils due to chronic infection or toxicity
  15. What is Neutropenia?
    <1000 cells (normal is 1800-7700)
  16. What is Neutrophilia?
    >8000 cells (normal 1800-7700)
  17. What is Eiosinophilia?
    >600 cells
  18. What two cells can stimulate Eiosinophils?
    Basophils and Mast Cells
  19. What are the three destructive enzymes of Eiosinophils?
    MBC, ECP, EPO
  20. What is the difference b/t an effector and a memory cell?
    • Effector: used now
    • Memory: used later when needed
  21. What is the main diff b/t T-cell and NK cell?
    • T-cell: activated by cells with MHC
    • NK cell: activated by cells w/o MHCI
  22. % monocytes in blood
    4-10%
  23. % PMN in blood
    70%
  24. % eiosinophils that are leukocytes
    2-5%
  25. % basophils that are leukocytes
    .5-1%
  26. What granulocytes are activate by complement factor C3a?
    Basophils and Mast cells
  27. % lymphocytes that are leukocytes
    20% - 30%
  28. % Lymphocytes that are B
    5-15%
  29. % lymphocytes that are T
    80%
  30. What cell is a major target of HIV and why?
    TH because of the high immunity it provides through its CD4 marker

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