Ocular Pharmacotherapeutics

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Author:
mackoymd
ID:
71546
Filename:
Ocular Pharmacotherapeutics
Updated:
2011-03-08 07:55:30
Tags:
Ophthalmology Pharmacotherapeutics
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Description:
Drugs used in the eyes
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  1. Secretion of the aqueous humor is known to depend largely on the active transport of what ion?
    Sodium by the Na+K+ATPase
  2. Na+K+ATPase is an enzyme responsible for the production of the aqueous humor. What drug can counteract its action?
    Ouabain
  3. Which ion can indirectly inhibit the production of aqueous humor ?
    HCO3-
  4. An enzyme that catalyzes the hydration of dissoved CO2 and H2CO3, which later on ionizes in HCO3- and H+.
    Carbonic Anhydrase
  5. The first PG analogue to be developed and approved, which a prodrug of PGF2-alpha that penetrates the cornea. It lowers IOP by enhancing uveoscleral outflow.
    Latanoprost (Xalatan)
  6. An ocular side effects of prostaglandin analogues
    melanogenesis (darkening of iris and periocular areas)
  7. A drug agent that reduces IOP and vitreous volume by increasing serum osmolarity that in turn draws fluid out of the eye across vascular barriers.
    Osmotic agents
  8. The most frequently used oral osmotic agent.
    Glycerine
  9. The most potent glucocorticoid and the same that induces the highest rise in IOP during chronic therapy
    Dexamethasone
  10. A fluorinated pyrimidine nucleoside analogue that blocks production of thymidylate and interrupts normal cellular DNA and RNA synthesis. Its primary action is to cause cellular thymide deficiency and resultant cell death.
    Fluorouracil
  11. It is a compound isolated from the fungus Streptomyces caespitosus. Its parent compound becomes a bifunctional alkylating agent after enzymatic alteration within the cell
    Mitomycin-C

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