BioChem Block 2
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1. Which of the following types of mutations can
lead to a cancer cell?
- Inhibition of a tumor suppressor gene
- Inhibition of a proto-oncogene
- Activation of a tumor suppressor gene
- Activation of a proto-oncogene
- None of the above
A and D
2. Which of the following are properties of
- They are contact inhibited.
- They readily enter apoptosis.
- They generally have mutations in repair mechanisms.
- They have inhibited their telomerase activities.
- They all have activated p53 genes.
3. How many different mutations are required to
convert a normal cell into a cancer cell?
4. How many mutant alleles are required at a
proto-oncogene locus for it to cause growth in an unregulated manner?
5. How many mutant alleles are required at a
tumor suppressor gene locus for it to cause growth in an unregulated manner?
6. Associate the folowing:
- Stimulation of GTP’ase activity
- Inactive form of a G protein
- Active form of a G protein
- Hypophosphorylated Rb1
- Hyperphosphorylated Rb1
- Activation of MYC
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