BioChem Block 2

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Author:
zhr47
ID:
71554
Filename:
BioChem Block 2
Updated:
2011-03-08 08:39:08
Tags:
USESOM biochem block2
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Description:
USESOM BioChem Block 2 review questions
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  1. 1. Which of the following types of mutations can
    lead to a cancer cell?




    1. Inhibition of a tumor suppressor gene







    2. Inhibition of a proto-oncogene







    3. Activation of a tumor suppressor gene







    4. Activation of a proto-oncogene







    5. None of the above



    A and D
  2. 2. Which of the following are properties of
    cancer cells?



    1. They are contact inhibited.



    2. They readily enter apoptosis.



    3. They generally have mutations in repair mechanisms.



    4. They have inhibited their telomerase activities.



    5. They all have activated p53 genes.


    C
  3. 3. How many different mutations are required to
    convert a normal cell into a cancer cell?




    1. 0





    2. 1





    3. 2





    4. 3





    5. Many



    E
  4. 4. How many mutant alleles are required at a
    proto-oncogene locus for it to cause growth in an unregulated manner?




    1. 0





    2. 1





    3. 2





    4. 3





    5. Many



    A
  5. 5. How many mutant alleles are required at a
    tumor suppressor gene locus for it to cause growth in an unregulated manner?




    1. 0





    2. 1





    3. 2





    4. 3





    5. Many



    B
  6. 6. Associate the folowing:




    1. Stimulation of GTP’ase activity





    2. Inactive form of a G protein





    3. Active form of a G protein





    4. p53





    5. Hypophosphorylated Rb1





    6. Hyperphosphorylated Rb1





    7. Activation of MYC






    ___
    E2F

    ___
    Beta catenin

    ___
    GTP

    ___
    GDP

    ___
    apoptosis

    ___
    Ras GAP

    • 7. Associate the following:

    • _E_ E2F

    • _G_ Beta catenin

    • _C_ GTP

    • _B_ GDP

    • _D_ apoptosis

    • _A_ Ras GAP

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