What is Xigris(R)? (generic name, actions, significance, when to start tx?, risk)
- drotrecogin alfa (activated)
- recombinant human activated protein C (APC)
- natural anticoagulant (inhibit factors Va and VIIIa)
- first time statistically significant dec of mortality!
- start w/i 48h of dx of severe sepsis
- risk is bleed but can transfuse