Hormones and their Actions

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Hormones and their Actions
2011-03-11 21:57:55
hormone endocrine biochem

Biochem lectures 55-56
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  1. ACTH
    adrenal growth and steroid production
  2. alpha-MSH
    Melanin dispersian in amphibians; Learning and sexual behavior; Growth and function of testicular sertoli cells
  3. beta-LPH
    Lipolysis and fatty acid mobilization
  4. beta-Endorphin
    Analgesia; Behavior (feeding, emotion, learning); Temperature and blood pressure regulation; COntraction of reproduction tract muscles
  5. N-terminal fragment
    Potentiation of ACTH action on steriodogenesis fragment
  6. Graves disease (hyperthyroidism)
    Ab stimulates TSH receptor
  7. Acanthosis Nigrans (insulin resistant)
    Ab blocks insulin binding
  8. Myasthenia gravis
    Ab enhances turnover of Ach receptor
  9. Asthma
    Ab blocks beta-adrenergic binding receptor
  10. Congenital nephrogenic diabetes insipidus
    ADH (vasopressin) receptor deficiency
  11. Pseudohypoparathyroidism
    PTH receptor deficiency
  12. Obesity
    Insulin binding decreased
  13. Diabetes mellitus type II. SOme forms of NIDDM
    Insulin binding decreased cus receptor is downregulated.
  14. Diabetes mellitus type I
    Deficiency of insulin
  15. Dwarfism
    Deficiency of growth hormone
  16. Gigantism, acromegaly
    Excess secretion of growth hormone
  17. Familial neurohypophyseal diabetes insipidus (FNDI)
    Mutations in ADH (vasopressin) prohormone decrease VP synthesis
  18. G-as
    beta-adrenergic amines; glucagon; PTH ------> Stimulates adenylate cyclase
  19. G-ai
    acetylecholine; alpha-adrenergic amines -----> Inhibits adenylate cyclase
  20. G-at
    photons -----> stimulate cGMP phosphodiesterase
  21. G-aq
    acetylecholine; alpha-adrenergic amines -----> increase IP3 and intracellular Ca2+
  22. G-a13
    Thrombin -----> Stimulate Na+ and H+ exchange