Card Set Information
ACLAM mice mouse genetic nomenclature
What type of mouse strain is represented by the following nomenclature? TAC:NIH Swiss
>/= 4 generations, with < 1% inbreeding/generation
2-4 capital letters and/or numbers
What type strain is designated by the following nomenclature? DBA/2J
Brother x Sister matings for >/= 20 generations
Unique symbol of uppercase letters, Roman letters, or a combination of letters and numbers beginning with a letter
What type of strain is designated by the following nomenclature? CXB6
Cross of two inbred strains
Follow with bro x sis matings for >/= 20 generations
Uppercase abbreviation of parent strains
Separate with �X� with no spaces
: C=BALB/c female; B6=C57BL/6 male
What type of strain is this? D2B6F1
Progeny of two inbred strains
Uppercase abbreviations of parents followed by �F1�
Further crosses are NOT genetically identical
What type of strain is designated by this nomenclature? 129S7/SvEvBrd-Fyntm1Sor
Inbred strain that differs from the original strain by a mutation at a single locus
Gene symbol in italics
What type of strain is shown here? B6.AKR-H2k
Repeated backcross to inbred strain
Selection for particular marker from donor strain
10 backcross generations
: 5 generations
Recipient strain symbol (full or abbrev.)
Abbreviated donor symbol
Differential allele from donor
Inbred strains in which an allele or mutation is maintained in a heterozygous state
Symbol looks just like other inbred strains
: 129P3/J and B6.Cg-m Leprdb/+ +
What type of strain is designated here? B6-mtCAS
Nuclear genome from male of one strain backcrossed onto cytoplasmic genome of female of another
10 backcrosses required
: NUCLEAR GENOME-mtCYTOPLASMIC GENOME
What type of strain is shown here? SHR-Chr YBN (Why yes, this is a rat!)
Consomic or Chromosome Substitution Strain
Repeat backcrossing of a whole chromosome onto an inbred strain
: HOST STRAIN-Chr #DONOR STRAIN
: Y chromosome from a BN rat backcrossed onto a SHR rat
Genetically Engineered Mice TgX(YYYYY)#####Zzz
: Tg for transgene + mode of insertion
N= Non-homologous insertion
R= Insertion via retroviral infection
H= Homologous recombination in embryonic stem cells
(YYYYY) is the insert designation
No more than 8 letters and/or numbers
##### is the Laboratory assigned number
Less than 5 characters. In combo with insert, less than 11
Zzz is the laboratory code
3-4 letters, first Uppercase
Who maintains the Code Registry? (ILAR)
B6 from Jackson Lab (J)
Bears human CD8 genomic clone (N=non-homologous insertion)
23rd mouse screened in the lab of Jon W. Gordon (Jwg)
What is the gene for the non-agouti coat color?
A or +
What is the gene for the Black coat color?
Tyrp1 or Tyrp+
What is the gene for a pigmnted coat color?
Tyr or Tyr+
(dominant over others)
What is the gene for a dilute coat color?
Myo5a or Myo5a+
What is the gene for pink-eyed dilution?
What is the gene for the Beige coat color?
Lyst (originally bg)
What is the gene for the piebald coat color?
Ednrb (originally s)
What lymphocytes are deficient in Nude (nu) mice and what is the associated chromosome?
T cells; Chromosome 11
What lymphocytes are deficient in SCID mice and what is the associated chromosome?
T and B cells; Chromosome 16
What lymphocytes are deficient in Beige mice and what is the associated chromosome?
Natural Killer Cells; Chromosome 13
What lymphocytes are deficient in Rag-1 and -2 Knockout mice?
T and B Cells
What lymphocytes are deficient in bg/nu/XID and SCID/bg mice?
T, B, and NK cells