Mouse nomenclature

Home > Preview

The flashcards below were created by user vet1999 on FreezingBlue Flashcards.


  1. What type of mouse strain is represented by the following nomenclature? TAC:NIH Swiss
    • Outbred Stock
    • >/= 4 generations, with < 1% inbreeding/generation
    • Laboratory Code
    • Colon
    • 2-4 capital letters and/or numbers
  2. What type strain is designated by the following nomenclature? DBA/2J
    • Inbred Strain
    • Brother x Sister matings for >/= 20 generations
    • Unique symbol of uppercase letters, Roman letters, or a combination of letters and numbers beginning with a letter
    • Other example: C3H
  3. What type of strain is designated by the following nomenclature? CXB6
    • Recombinant Inbred
    • Cross of two inbred strains
    • Follow with bro x sis matings for >/= 20 generations
    • Uppercase abbreviation of parent strains
    • Female first
    • Separate with �X� with no spaces
    • For CXB6: C=BALB/c female; B6=C57BL/6 male
  4. What type of strain is this? D2B6F1
    • F1 Hybrid
    • Progeny of two inbred strains
    • Uppercase abbreviations of parents followed by �F1�
    • Genetically identical
    • Further crosses are NOT genetically identical
  5. What type of strain is designated by this nomenclature? 129S7/SvEvBrd-Fyntm1Sor
    • Coisogenic
    • Inbred strain that differs from the original strain by a mutation at a single locus
    • Strain symbol: 129S7/SvEvBrd
    • Then hyphen: -
    • Gene symbol in italics: Fyntm1Sor
  6. What type of strain is shown here? B6.AKR-H2k
    • Congenic
    • Repeated backcross to inbred strain
    • Selection for particular marker from donor strain
    • 10 backcross generations
    • �Speed congenics�: 5 generations
    • Recipient strain symbol (full or abbrev.): B6
    • Period: .
    • Abbreviated donor symbol: AKR
    • Hyphen: -
    • Differential allele from donor
  7. Segregating Inbred
    • Inbred strains in which an allele or mutation is maintained in a heterozygous state
    • Symbol looks just like other inbred strains
    • Examples: 129P3/J and B6.Cg-m Leprdb/+ +
  8. What type of strain is designated here? B6-mtCAS
    • Conplastic
    • Nuclear genome from male of one strain backcrossed onto cytoplasmic genome of female of another
    • 10 backcrosses required
    • Designation: NUCLEAR GENOME-mtCYTOPLASMIC GENOME
  9. What type of strain is shown here? SHR-Chr YBN (Why yes, this is a rat!)
    • Consomic or Chromosome Substitution Strain
    • Repeat backcrossing of a whole chromosome onto an inbred strain
    • 10 backcrosses
    • Designation: HOST STRAIN-Chr #DONOR STRAIN
    • SHR-Chr YBN: Y chromosome from a BN rat backcrossed onto a SHR rat
  10. Genetically Engineered Mice TgX(YYYYY)#####Zzz
    • TgX: Tg for transgene + mode of insertion
    • N= Non-homologous insertion
    • R= Insertion via retroviral infection
    • H= Homologous recombination in embryonic stem cells
    • GEM
    • (YYYYY) is the insert designation
    • No more than 8 letters and/or numbers
    • ##### is the Laboratory assigned number
    • Less than 5 characters. In combo with insert, less than 11
    • Zzz is the laboratory code
    • 3-4 letters, first Uppercase
    • Who maintains the Code Registry? (ILAR)
    • GEM Example
    • C57BL/6J-TgN(CD8Ge)23Jwg
    • B6 from Jackson Lab (J)
    • Bears human CD8 genomic clone (N=non-homologous insertion)
    • 23rd mouse screened in the lab of Jon W. Gordon (Jwg)
  11. What is the gene for the non-agouti coat color?
    • a: Non-agouti
    • A or +: Agouti
    • Chromosome? 2
  12. What is the gene for the Black coat color?
    • Tyrp1 or Tyrp+: Black
    • Tyrp1b: Brown
    • Chromosome? 4
  13. What is the gene for a pigmnted coat color?
    • Tyr or Tyr+: Pigmented
    • Tyrc: Albino
    • (dominant over others)
    • Tyrc-ch: Chinchilla
    • Chromosome? 7
  14. What is the gene for a dilute coat color?
    • Myo5a or Myo5a+: Non-dilute
    • Myo5ad: Dilute
    • Chromosome? 9
  15. What is the gene for pink-eyed dilution?
    • Lowercase p
    • Chromosome? 7
  16. What is the gene for the Beige coat color?
    • Lyst (originally bg)
    • Chromosome 13
  17. What is the gene for the piebald coat color?
    • Ednrb (originally s)
    • Chromosome 14
  18. What lymphocytes are deficient in Nude (nu) mice and what is the associated chromosome?
    T cells; Chromosome 11
  19. What lymphocytes are deficient in SCID mice and what is the associated chromosome?
    T and B cells; Chromosome 16
  20. What lymphocytes are deficient in Beige mice and what is the associated chromosome?
    Natural Killer Cells; Chromosome 13
  21. What lymphocytes are deficient in Rag-1 and -2 Knockout mice?
    T and B Cells
  22. What lymphocytes are deficient in bg/nu/XID and SCID/bg mice?
    T, B, and NK cells

Card Set Information

Author:
vet1999
ID:
72381
Filename:
Mouse nomenclature
Updated:
2011-03-12 15:31:27
Tags:
ACLAM mice mouse genetic nomenclature
Folders:

Description:
Mouse nomenclature
Show Answers:

Home > Flashcards > Print Preview