Mouse nomenclature

Card Set Information

Author:
vet1999
ID:
72381
Filename:
Mouse nomenclature
Updated:
2011-03-12 10:31:27
Tags:
ACLAM mice mouse genetic nomenclature
Folders:

Description:
Mouse nomenclature
Show Answers:

Home > Flashcards > Print Preview

The flashcards below were created by user vet1999 on FreezingBlue Flashcards. What would you like to do?


  1. What type of mouse strain is represented by the following nomenclature? TAC:NIH Swiss
    • Outbred Stock
    • >/= 4 generations, with < 1% inbreeding/generation
    • Laboratory Code
    • Colon
    • 2-4 capital letters and/or numbers
  2. What type strain is designated by the following nomenclature? DBA/2J
    • Inbred Strain
    • Brother x Sister matings for >/= 20 generations
    • Unique symbol of uppercase letters, Roman letters, or a combination of letters and numbers beginning with a letter
    • Other example: C3H
  3. What type of strain is designated by the following nomenclature? CXB6
    • Recombinant Inbred
    • Cross of two inbred strains
    • Follow with bro x sis matings for >/= 20 generations
    • Uppercase abbreviation of parent strains
    • Female first
    • Separate with �X� with no spaces
    • For CXB6: C=BALB/c female; B6=C57BL/6 male
  4. What type of strain is this? D2B6F1
    • F1 Hybrid
    • Progeny of two inbred strains
    • Uppercase abbreviations of parents followed by �F1�
    • Genetically identical
    • Further crosses are NOT genetically identical
  5. What type of strain is designated by this nomenclature? 129S7/SvEvBrd-Fyntm1Sor
    • Coisogenic
    • Inbred strain that differs from the original strain by a mutation at a single locus
    • Strain symbol: 129S7/SvEvBrd
    • Then hyphen: -
    • Gene symbol in italics: Fyntm1Sor
  6. What type of strain is shown here? B6.AKR-H2k
    • Congenic
    • Repeated backcross to inbred strain
    • Selection for particular marker from donor strain
    • 10 backcross generations
    • �Speed congenics�: 5 generations
    • Recipient strain symbol (full or abbrev.): B6
    • Period: .
    • Abbreviated donor symbol: AKR
    • Hyphen: -
    • Differential allele from donor
  7. Segregating Inbred
    • Inbred strains in which an allele or mutation is maintained in a heterozygous state
    • Symbol looks just like other inbred strains
    • Examples: 129P3/J and B6.Cg-m Leprdb/+ +
  8. What type of strain is designated here? B6-mtCAS
    • Conplastic
    • Nuclear genome from male of one strain backcrossed onto cytoplasmic genome of female of another
    • 10 backcrosses required
    • Designation: NUCLEAR GENOME-mtCYTOPLASMIC GENOME
  9. What type of strain is shown here? SHR-Chr YBN (Why yes, this is a rat!)
    • Consomic or Chromosome Substitution Strain
    • Repeat backcrossing of a whole chromosome onto an inbred strain
    • 10 backcrosses
    • Designation: HOST STRAIN-Chr #DONOR STRAIN
    • SHR-Chr YBN: Y chromosome from a BN rat backcrossed onto a SHR rat
  10. Genetically Engineered Mice TgX(YYYYY)#####Zzz
    • TgX: Tg for transgene + mode of insertion
    • N= Non-homologous insertion
    • R= Insertion via retroviral infection
    • H= Homologous recombination in embryonic stem cells
    • GEM
    • (YYYYY) is the insert designation
    • No more than 8 letters and/or numbers
    • ##### is the Laboratory assigned number
    • Less than 5 characters. In combo with insert, less than 11
    • Zzz is the laboratory code
    • 3-4 letters, first Uppercase
    • Who maintains the Code Registry? (ILAR)
    • GEM Example
    • C57BL/6J-TgN(CD8Ge)23Jwg
    • B6 from Jackson Lab (J)
    • Bears human CD8 genomic clone (N=non-homologous insertion)
    • 23rd mouse screened in the lab of Jon W. Gordon (Jwg)
  11. What is the gene for the non-agouti coat color?
    • a: Non-agouti
    • A or +: Agouti
    • Chromosome? 2
  12. What is the gene for the Black coat color?
    • Tyrp1 or Tyrp+: Black
    • Tyrp1b: Brown
    • Chromosome? 4
  13. What is the gene for a pigmnted coat color?
    • Tyr or Tyr+: Pigmented
    • Tyrc: Albino
    • (dominant over others)
    • Tyrc-ch: Chinchilla
    • Chromosome? 7
  14. What is the gene for a dilute coat color?
    • Myo5a or Myo5a+: Non-dilute
    • Myo5ad: Dilute
    • Chromosome? 9
  15. What is the gene for pink-eyed dilution?
    • Lowercase p
    • Chromosome? 7
  16. What is the gene for the Beige coat color?
    • Lyst (originally bg)
    • Chromosome 13
  17. What is the gene for the piebald coat color?
    • Ednrb (originally s)
    • Chromosome 14
  18. What lymphocytes are deficient in Nude (nu) mice and what is the associated chromosome?
    T cells; Chromosome 11
  19. What lymphocytes are deficient in SCID mice and what is the associated chromosome?
    T and B cells; Chromosome 16
  20. What lymphocytes are deficient in Beige mice and what is the associated chromosome?
    Natural Killer Cells; Chromosome 13
  21. What lymphocytes are deficient in Rag-1 and -2 Knockout mice?
    T and B Cells
  22. What lymphocytes are deficient in bg/nu/XID and SCID/bg mice?
    T, B, and NK cells

What would you like to do?

Home > Flashcards > Print Preview