PHARMOCOLOGY 100 CH 3

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leti563
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72518
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PHARMOCOLOGY 100 CH 3
Updated:
2011-03-13 04:00:51
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PHAR 100 CH 3
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  1. Sources of Drugs
    • Plants
    • Minerals
    • Animals
    • Synthetics
  2. Systemic
    Effects of Drugs
    First absorbed into te bloodstream, in order to be delivered to the site of action.
  3. Local
    Effects of Drugs
    Action is intended to be limite to area of administration.
  4. Pharmacodynamics
    Action when drug changes the bodys function (physiology) to achieve its esired effects.
  5. Pharmacokinetics
    • Process in which a drug moves through the body.
    • (4 stages)
  6. Pharmacokinetics
    (4 Stages)
    • Absorption
    • Distribution
    • Metabolism
    • Excretion
  7. Absorption
    (Systemic Circulation)
    • Mouth
    • Stomach
    • Intestines
    • Blood Vessels
    • Muscles
    • Skin
  8. Distribution
    • Where Drug Goes
    • From bloodstream to tissues

    • Water Soluble- Stay in blood longer
    • Fat Soluble- Stored in fat
  9. Metabolism
    Physical & chemical alterations that occur during drug actions.

    • Main site: Liver
    • Affected by : Cirrhosis, hepatitis
  10. Excretion
    • Elimination of drug Waste.
    • Main site: Kidneys
    • Affected by: Renal failure
    • Can lead to: Toxicity Cummulative effects.
  11. Drug Interactions
    Synergism
    2 drugs act together for increased effects.
  12. Drug Interactions
    Antagonism
    One Drug can increase or cancel out the effect of another drug.

    May be desired or not.
  13. Drug Dosage
    (7 Levels)
    • Minimum
    • Maximum
    • Loading
    • Maintenance
    • Toxic
    • Lethal
    • Therapeutic
  14. Enternal Routes of administration.
    Digestive System
    • Oral
    • Nasogastric
    • Rectal
  15. Nasogastric Admninistration
    • Bypasses mouth
    • Avoids repeated injections
  16. Parenteral Route of Administration
    Any route other than gastrointestinal System.
  17. Sublingual Route
    Parenteral
    • Under tongue
    • Rapid absorption
  18. Intramuscular injection
    (Most common)
    • Deltoid
    • Gluteus Maximus
    • Vastus Laterallis- (Children and infants)
  19. Injectable Subcutaneous
    (Sub Q)
    • Into connective Tissue
    • Between skin (dermis) and the muscle
  20. Injectable Intradermal
    (ID)
    Solution injected into dermis of skin to create a "Wheal"
  21. Topical Routes
    (Derma)
    • Absorbed through the skin
    • May be used for local or systemis effects
  22. Topical Route
    (Mucosa)
    • Eyes
    • Ears
    • Nose
    • Mouth
    • Vagina
    • Rectum
  23. Adverse Drug Effects
    • Teratogenic Effect
    • Paradoxical Effect
    • Tolerance
    • Dependence
    • Hypersensitivity (allergic Reaction)
  24. Hypersensitivity
    (Mild Reaction)
    • Urticaria- Hives
    • Hyperemia_Redness
    • Prutitis- Itching
  25. Hypersensitivity
    (Severe Reaction) ANYPHALAXIS
    • Anaphylaxis- Svere Reaction
    • DyspneaLaryngeal Edema

    • Circulatory Collapse
  26. Anaphylaxis Treatment
    • Epinephrine- Vasoconstricter
    • Steroids- Reduse Inflamation
    • Antihistamine-reduce Redness and Itching

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