Drug-Drug: ↑ hypotension with antihypertensives, nitrates, or acute ingestion of alcohol. ↑ risk of hypokalemia with other diuretics, amphotericin B, stimulant laxatives, and corticosteroids. Hypokalemia may ↑ risk of digoxin toxicity and ↑ risk of arrhythmia in patients taking drugs that prolong the QT interval. ↓ lithium excretion, may cause lithiumtoxicity. ↑ risk of ototoxicity with aminoglycosides. NSAIDS↓ effects of furosemide.